Evidence map›Paper›PMID 25805886›Full record

Trial reportSchizophrenia bulletin2015

The Impact of Aerobic Exercise on Brain-Derived Neurotrophic Factor and Neurocognition in Individuals With Schizophrenia: A Single-Blind, Randomized Clinical Trial.

David Kimhy, Julia Vakhrusheva, Matthew N Bartels, Hilary F Armstrong, Jacob S Ballon, Samira Khan, Rachel W Chang, Marie C Hansen, Lindsey Ayanruoh, Amanda Lister and 3 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 96 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 16 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02716584 nacompletednot on this mapstarted 2016, after this paper: background citation

Physical Exercise Effects on Determinants of Social Integration in Schizophrenia

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2016 to 2018Enrolled53ConditionsSchizophreniaArmsPhysical exercise, Stretching exercise
NCT03270098 nacompletednot on this mapstarted 2018, after this paper: background citation

Improving Cognition Via Exercise in Schizophrenia

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2018 to 2023Enrolled104ConditionsSchizophrenia and Related DisordersArmsAerobic Exercise, Stretching and Toning Exercise
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 16 syntheses or guidelines pooled it, 204 citations in OpenAlex.

  1. Pooled it
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  3. Exercise to treat psychopathology and other clinical outcomes in schizophrenia: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2023
    Pooled it
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  6. Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021
    Pooled it
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  10. Yoga as part of a package of care versus standard care for schizophrenia.The Cochrane database of systematic reviews · 2017
    Pooled it
  11. Yoga versus non-standard care for schizophrenia.The Cochrane database of systematic reviews · 2017
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  17. Trial
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

David KimhyDepartment of Psychiatry, Columbia University, New York, NY; New York State Psychiatric Institute, New York, NY; kimhyda@nyspi.columbia.edu.
Julia VakhrushevaDepartment of Psychiatry, Columbia University, New York, NY;
Matthew N BartelsDepartment of Rehabilitation Medicine, Albert Einstein College of Medicine, Bronx, NY;
Hilary F ArmstrongDepartment of Rehabilitation & Regenerative Medicine, Columbia University, New York, NY;
Jacob S BallonDepartment of Psychiatry, Columbia University, New York, NY; New York State Psychiatric Institute, New York, NY;
Samira KhanNew York State Psychiatric Institute, New York, NY;
Rachel W ChangNew York State Psychiatric Institute, New York, NY;
Marie C HansenNew York State Psychiatric Institute, New York, NY;
Lindsey AyanruohNew York State Psychiatric Institute, New York, NY;
Amanda ListerNew York State Psychiatric Institute, New York, NY;
Eero CastrénNeuroscience Center, University of Helsinki, Helsinki, Finland.
Edward E SmithDepartment of Psychiatry, Columbia University, New York, NY; New York State Psychiatric Institute, New York, NY;
Richard P SloanDepartment of Psychiatry, Columbia University, New York, NY; New York State Psychiatric Institute, New York, NY;
New York State Psychiatric InstituteColumbia University · USNew York Psychoanalytic Society and Institute · USAlbert Einstein College of Medicine · USUniversity of Helsinki · FI

Funding

The Influence of Aerobic Exercise on Cognitive Functioning in SchizophreniaR21MH096132 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIMHY, DAVID · 2012 to 2013
$432k
NIMH NIH HHS 1R21MH096132NIMH NIH HHS R21 MH096132
6 · The paper itself

Abstract

Individuals with schizophrenia display substantial neurocognitive deficits for which available treatments offer only limited benefits. Yet, findings from studies of animals, clinical and nonclinical populations have linked neurocognitive improvements to increases in aerobic fitness (AF) via aerobic exercise training (AE). Such improvements have been attributed to up-regulation of brain-derived neurotrophic factor (BDNF). However, the impact of AE on neurocognition, and the putative role of BDNF, have not been investigated in schizophrenia. Employing a proof-of-concept, single-blind, randomized clinical trial design, 33 individuals with schizophrenia were randomized to receive standard psychiatric treatment (n = 17; "treatment as usual"; TAU) or attend a 12-week AE program (n = 16) utilizing active-play video games (Xbox 360 Kinect) and traditional AE equipment. Participants completed assessments of AF (indexed by VO2 peak ml/kg/min), neurocognition (MATRICS Consensus Cognitive Battery), and serum-BDNF before and after and 12-week period. Twenty-six participants (79%) completed the study. At follow-up, the AE participants improved their AF by 18.0% vs a -0.5% decline in the TAU group (P = .002) and improved their neurocognition by 15.1% vs -2.0% decline in the TAU group (P = .031). Hierarchical multiple regression analyses indicated that enhancement in AF and increases in BDNF predicted 25.4% and 14.6% of the neurocognitive improvement variance, respectively. The results indicate AE is effective in enhancing neurocognitive functioning in people with schizophrenia and provide preliminary support for the impact of AE-related BDNF up-regulation on neurocognition in this population. Poor AF represents a modifiable risk factor for neurocognitive dysfunction in schizophrenia for which AE training offer a safe, nonstigmatizing, and side-effect-free intervention.

Indexed as

Cognition DisordersSchizophreniaAdultBrain-Derived Neurotrophic FactorExerciseExercise TherapyFemaleHumansMaleMiddle AgedPhysical FitnessSingle-Blind MethodTreatment OutcomeVideo GamesBDNF protein, humanBrain-Derived Neurotrophic Factoraerobic fitnessbrain-derived neurotrophic factor/active-play video gamescognitionneurotrophins

Identifiers

PMID25805886
PMCPMC4466187
OpenAlexW2161120457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.