Evidence map›Paper›PMID 25805871›Full record

ArticleDiabetes care2015

Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy.

Jing Hughes, Nalini Vudattu, Mario Sznol, Scott Gettinger, Harriet Kluger, Beatrice Lupsa, Kevan C Herold

Abstract readCase ReportsLetter
In one paragraph

Article in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Immune checkpoint inhibitor-induced Type 1 diabetes: a systematic review and meta-analysis.Diabetic medicine : a journal of the British Diabetic Association · 2019
    Pooled it
  5. Efficacy of nivolumab as checkpoint inhibitor drug on survival rate of patients with relapsed/refractory classical Hodgkin lymphoma: a meta-analysis of prospective clinical study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019
    Pooled it
  6. Pooled it
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  13. 3-in-oneiScience · 2025
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115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing HughesDepartment of Immunobiology, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT Section of Endocrinology and Metabolism, Yale University School of Medicine, New Haven, CT.
Nalini VudattuDepartment of Immunobiology, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT.
Mario SznolDepartment of Internal Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT.
Scott GettingerDepartment of Internal Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT.
Harriet KlugerDepartment of Internal Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT.
Beatrice LupsaSection of Endocrinology and Metabolism, Yale University School of Medicine, New Haven, CT.
Kevan C HeroldDepartment of Immunobiology, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT Section of Endocrinology and Metabolism, Yale University School of Medicine, New Haven, CT kevan.herold@yale.edu.

Funding

Phase II Trial of HOKT3gamma 1 (ALA-ALA) in Type 1 DiabetesR01DK057846 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold · 2000 to 2026
$11.1M
DIABETES MELLITUS &DISORDERS OF METABOLISMT32DK007058 · NIDDK · YALE UNIVERSITY · PI SONIA CAPRIO, Kevan C Herold · 1986 to 2026
$9.6M
NIDDK NIH HHS R01 DK057846NIDDK NIH HHS R01DK057846NIDDK NIH HHS T32 DK007058NIDDK NIH HHS T32DK007058
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aged, 80 and overAntibodies, MonoclonalAutoimmunityDiabetes Mellitus, Type 1Disease ProgressionFemaleHumansImmunotherapyMaleMiddle AgedNeoplasmsNivolumabProgrammed Cell Death 1 ReceptorAntibodies, MonoclonalNivolumabPDCD1 protein, humanProgrammed Cell Death 1 Receptor

Identifiers

PMID25805871
PMCPMC4370325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.