ArticleGenes & development2015
Phenotypic evolution through variation in splicing of the noncoding RNA COOLAIR.
Article in Genes & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Molecular integration of seasonal temperature signals in flowering time control.Nature reviews. Genetics · 2026Review
- Constitutive overexpression of GRF21, a 14-3-3 family protein, delays flowering time in maize (Zea mays).BMC plant biology · 2026Article
- OsCPK9-mediated Thr105 phosphorylation activates OsCATC to enhance drought tolerance in rice.Journal of advanced research · 2026Article
- Integrative linkage mapping, GWAS, and RNA-Seq analysis unravel the genetic architecture and candidate genes for drought tolerance inHorticulture research · 2025Article
- Cooperative condensation of RNA-DIRECTED DNA METHYLATION 16 splicing isoforms enhances heat tolerance in Arabidopsis.Nature communications · 2025Article
- All roads lead to Rome: QTL analysis for vernalization requirement and dissection of allelic variation uncovered unexpected diversity ofFrontiers in plant science · 2025Article
- Cotranscriptional splicing is required in the cold to produceProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Retrotransposon-driven environmental regulation of FLC leads to adaptive response to herbicide.Nature plants · 2024Article
- Transcription regulation by long non-coding RNAs: mechanisms and disease relevance.Nature reviews. Molecular cell biology · 2024Review
- Flowering time: From physiology, through genetics to mechanism.Plant physiology · 2024Review
- SISTER OF FCA physically associates with SKB1 to regulate flowering time in Arabidopsis thaliana.BMC plant biology · 2024Article
- Abscisic-acid-responsiveFrontiers in plant science · 2024Article
- Fine mapping and analysis of candidate genes for qBT2 and qBT7.2 locus controlling bolting time in radish (Raphanus sativus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Responsiveness to long days for flowering is reduced in Arabidopsis by yearly variation in growing season temperatures.Plant, cell & environment · 2023Article
- Regulation of Flowering Time and Other Developmental Plasticities by 3' Splicing Factor-Mediated Alternative Splicing inPlants (Basel, Switzerland) · 2023Review
- The P-body component DECAPPING5 and the floral repressor SISTER OF FCA regulate FLOWERING LOCUS C transcription in Arabidopsis.The Plant cell · 2023Article
- Article
- Long non-coding RNAs: definitions, functions, challenges and recommendations.Nature reviews. Molecular cell biology · 2023Review
- Rock, scissors, paper: How RNA structure informs function.The Plant cell · 2023Article
- Cotranscriptional RNA processing and modification in plants.The Plant cell · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The extent to which natural polymorphisms in noncoding sequences have functional consequences is still unknown. A large proportion of the natural variation in flowering in Arabidopsis thaliana accessions is due to noncoding cis polymorphisms that define distinct haplotypes of FLOWERING LOCUS C (FLC). Here, we show that a single natural intronic polymorphism in one haplotype affects FLC expression and thus flowering by specifically changing splicing of the FLC antisense transcript COOLAIR. Altered antisense splicing increases FLC expression via a cotranscriptional mechanism involving capping of the FLC nascent transcript. Single noncoding polymorphisms can therefore be a major contributor to phenotypic evolution through modulation of noncoding transcripts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.