ArticleGenome biology and evolution2015
Whole-genome sequencing of six Mauritian Cynomolgus macaques (Macaca fascicularis) reveals a genome-wide pattern of polymorphisms under extreme population bottleneck.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Differences in cynomolgus macaque populations used for infectious disease research.Animal models and experimental medicine · 2026Review
- Genomic Evidence for the Complex Evolutionary History of Macaques (Genus Macaca).Journal of molecular evolution · 2024Article
- The phylogenetic relationship and demographic history of rhesus macaques (Ecology and evolution · 2024Article
- DNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species.Evolutionary applications · 2024Article
- Demographic History of the Brown Bear (Ursus arctos) on Hokkaido Island, Japan, Based on Whole-Genomic Sequence Analysis.Genome biology and evolution · 2021Article
- Population genomics reveal rapid genetic differentiation in a recently invasive population of Rattus norvegicus.Frontiers in zoology · 2021Article
- VDJ Gene Usage in IgM Repertoires of Rhesus and Cynomolgus Macaques.Frontiers in immunology · 2021Article
- Identifying a Minor Histocompatibility Antigen in Mauritian Cynomolgus Macaques Encoded byFrontiers in immunology · 2020Article
- MACSNVdb: a high-quality SNV database for interspecies genetic divergence investigation among macaques.Database : the journal of biological databases and curation · 2020Article
- Review
- Cynomolgus macaque IL37 polymorphism and control of SIV infection.Scientific reports · 2019Article
- RNA sequencing of kidney and liver transcriptome obtained from wild cynomolgus macaque (Macaca fascicularis) originating from Peninsular Malaysia.BMC research notes · 2018Article
- Identification and characterization of short tandem repeats in the Tibetan macaque genome based on resequencing data.Zoological research · 2018Article
- Whole genome sequencing in the search for genes associated with the control of SIV infection in the Mauritian macaque model.Scientific reports · 2018Article
- Single nucleotide polymorphisms in the FcγR3A and TAP1 genes impact ADCC in cynomolgus monkey PBMCs.Immunogenetics · 2017Article
- Diversity and regulatory impact of copy number variation in the primate Macaca fascicularis.BMC genomics · 2017Article
- Article
- The Population Genetic Composition of Conventional and SPF Colonies of Rhesus Macaques (Macaca mulatta) at the Caribbean Primate Research Center.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- The conservation genetics juggling act: integrating genetics and ecology, science and policy.Evolutionary applications · 2016Article
- Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cynomolgus macaques (Macaca fascicularis) were introduced to the island of Mauritius by humans around the 16th century. The unique demographic history of the Mauritian cynomolgus macaques provides the opportunity to not only examine the genetic background of well-established nonhuman primates for biomedical research but also understand the effect of an extreme population bottleneck on the pattern of polymorphisms in genomes. We sequenced the whole genomes of six Mauritian cynomolgus macaques and obtained an average of 20-fold coverage of the genome sequences for each individual. The overall level of nucleotide diversity was 23% smaller than that of the Malaysian cynomolgus macaques, and a reduction of low-frequency polymorphisms was observed. In addition, we also confirmed that the Mauritian cynomolgus macaques were genetically closer to a representative of the Malaysian population than to a representative of the Indochinese population. Excess of nonsynonymous polymorphisms in low frequency, which has been observed in many other species, was not very strong in the Mauritian samples, and the proportion of heterozygous nonsynonymous polymorphisms relative to synonymous polymorphisms is higher within individuals in Mauritian than Malaysian cynomolgus macaques. Those patterns indicate that the extreme population bottleneck made purifying selection overwhelmed by the power of genetic drift in the population. Finally, we estimated the number of founding individuals by using the genome-wide site frequency spectrum of the six samples. Assuming a simple demographic scenario with a single bottleneck followed by exponential growth, the estimated number of founders (∼20 individuals) is largely consistent with previous estimates.
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