ArticlemBio2015
Malaria parasites produce volatile mosquito attractants.
Article in mBio, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 74 citations in OpenAlex.
- Diurnal variation in expired breath volatiles in malaria-infected and healthy volunteers.Journal of breath research · 2018Trial
- Trial
- Making scents of mosquito lures: semiochemical attractants for adult mosquitoes.Parasites & vectors · 2026Review
- Breath Biomarkers of Pediatric Malaria: Reproducibility and Response to Antimalarial Therapy.The Journal of infectious diseases · 2024Article
- NAD activates olfactory receptor 1386 to regulate type I interferon responses inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Smelly interactions: host-borne volatile organic compounds triggering behavioural responses in mosquitoes, sand flies, and ticks.Parasites & vectors · 2024Review
- The volatilome signatures of Plasmodium falciparum parasites during the intraerythrocytic development cycle in vitro under exposure to artemisinin drug.Scientific reports · 2023Article
- Pathogen-Mediated Alterations of Insect Chemical Communication: From Pheromones to Behavior.Pathogens (Basel, Switzerland) · 2023Review
- Soap application alters mosquito-host interactions.iScience · 2023Article
- Avian Malaria Parasites Modulate Gut Microbiome Assembly in Canaries.Microorganisms · 2023Article
- A volatile sex attractant of tsetse flies.Science (New York, N.Y.) · 2023Article
- Manipulation by Plasmodium Parasites of Anopheles Mosquito Behavior and Human Odors.Acta parasitologica · 2022Review
- Article
- Breath Metabolites to Diagnose Infection.Clinical chemistry · 2021Review
- The Potential Use of Volatile Biomarkers for Malaria Diagnosis.Diagnostics (Basel, Switzerland) · 2021Review
- A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms.Scientific reports · 2021Article
- Mosquito Attractants.Journal of chemical ecology · 2021Review
- Olfaction in Anopheles mosquitoes.Chemical senses · 2021Review
- The Malaria Metabolite HMBPP Does Not Trigger Erythrocyte Terpene Release.ACS infectious diseases · 2020Article
- Evolution of isoprenyl diphosphate synthase-like terpene synthases in fungi.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledThe malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid organelle that possesses plant-like metabolic pathways. Plants use the plastidial isoprenoid biosynthesis pathway to produce volatile odorants, known as terpenes. In this work, we describe the volatile chemical profile of cultured malaria parasites. Among the identified compounds are several plant-like terpenes and terpene derivatives, including known mosquito attractants. We establish the molecular identity of the odorant receptors of the malaria mosquito vector Anopheles gambiae, which responds to these compounds. The malaria parasite produces volatile signals that are recognized by mosquitoes and may thereby mediate host attraction and facilitate transmission. IMPORTANCE: Malaria is a key global health concern. Mosquitoes that transmit malaria are more attracted to malaria parasite-infected mammalian hosts. These studies aimed to understand the chemical signals produced by malaria parasites; such an understanding may lead to new transmission-blocking strategies or noninvasive malaria diagnostics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.