Trial reportCirculation. Cardiovascular quality and outcomes2015
Cluster-randomized trial of a physician/pharmacist collaborative model to improve blood pressure control.
2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Circulation. Cardiovascular quality and outcomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 76 papers, 19 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 19 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Collaborative Model to Improve BP Control and Minimize Racial Disparities-CCC
A Coordinated PCP-Cardiologist Telemedicine Model (PCTM) in China's Community Hypertension Care: Study Protocol for a Randomized Controlled Trial
Who cites it
76 citing papers in PubMed, 19 syntheses or guidelines pooled it.
- Pharmacist-integrated collaborative outpatient care for risk factor control across the cardiovascular-kidney-metabolic spectrum: a systematic review and meta-analysis of randomized trials.Frontiers in medicine · 2026Pooled it
- Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Pooled it
- Can integrated care interventions strengthen primary care and improve outcomes for patients with chronic diseases? A systematic review and meta-analysis.Health research policy and systems · 2025Pooled it
- Education programmes for people with chronic kidney disease and diabetes.The Cochrane database of systematic reviews · 2024Pooled it
- Role of Health Care Professionals in the Success of Blood Pressure Control Interventions in Patients With Hypertension: A Meta-Analysis.Circulation. Cardiovascular quality and outcomes · 2024Pooled it
- Involving community pharmacists in interprofessional collaboration in primary care: a systematic review.BMC primary care · 2024Pooled it
- Remote follow-up by pharmacists for blood pressure control in patients with hypertension: a systematic review and a meta-analysis of randomized controlled trials.Scientific reports · 2024Pooled it
- Interprofessional collaboration in primary care: what effect on patient health? A systematic literature review.BMC primary care · 2023Pooled it
- Effectiveness and Cost-Effectiveness of Team-Based Care for Hypertension: A Meta-Analysis and Simulation Study.Hypertension (Dallas, Tex. : 1979) · 2023Pooled it
- Disparities in Prevalence and Barriers to Hypertension Control: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- The Effectiveness of Pharmacist Interventions in the Management of Patient with Renal Failure: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Improving Blood Pressure Management in Primary Care Patients with Chronic Kidney Disease: a Systematic Review of Interventions and Implementation Strategies.Journal of general internal medicine · 2020Pooled it
- Pharmacist's role in hypertension management: a review of key randomized controlled trials.Journal of human hypertension · 2020Pooled it
- 2019 AHA/ACC Clinical Performance and Quality Measures for Adults With High Blood Pressure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.Journal of the American College of Cardiology · 2019Guideline
- 2019 AHA/ACC Clinical Performance and Quality Measures for Adults With High Blood Pressure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.Circulation. Cardiovascular quality and outcomes · 2019Guideline
- Cost Effectiveness of Advanced Pharmacy Services Provided in the Community and Primary Care Settings: A Systematic Review.PharmacoEconomics · 2019Pooled it
- Economic evaluations of pharmacist-led medication review in outpatients with hypertension, type 2 diabetes mellitus, and dyslipidaemia: a systematic review.The European journal of health economics : HEPAC : health economics in prevention and care · 2019Pooled it
- Pharmacist services for non-hospitalised patients.The Cochrane database of systematic reviews · 2018Pooled it
- Comparative Effectiveness of Implementation Strategies for Blood Pressure Control in Hypertensive Patients: A Systematic Review and Meta-analysis.Annals of internal medicine · 2018Pooled it
- Real-World Effectiveness in Hypertension and Hyperlipidemia Collaborative Management between Pharmacies and Primary Care in Portugal: A Multicenter Pragmatic Controlled Trial (USFarmáciaInternational journal of environmental research and public health · 2023Trial
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Barry L CarterFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.). barry-carter@uiowa.edu.
Christopher S CoffeyFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.).
Gail ArderyFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.).
Liz UribeFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.).
Dixie EcklundFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.).
Paul JamesFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.).
Brent EganFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.).
Mark Vander WegFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.).
Elizabeth ChrischillesFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.).
Thomas VaughnFrom the Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City (B.L.C., G.A.); Departments of Family Medicine (B.L.C., P.J.) and Internal Medicine (M.V.W.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; Departments of Biostatistics (C.S.C., L.U., D.E.), Epidemiology (E.C.), and Health Management and Policy (T.V.), College of Public Health, University of Iowa, Iowa City; Department of Psychology (M.V.W.) and Organizations, Systems, and Community Health Area, College of Nursing (T.V.), University of Iowa, Iowa City; The Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Administration, IA (B.L.C., M.V.W.); and Department of Internal Medicine, University of South Carolina School of Medicine, Greenville (B.E.).
Funding
MEDication Focused Outpatient Care for Underutilization of Secondary PreventionR18HL116259 · NHLBI · UNIVERSITY OF IOWA · PI COFFEY, CHRISTOPHER S., KENNELTY, KOREY A · 2014 to 2018
$8.8MA collaborative model to improve BP control and minimize racial disparities-CCCR01HL091841 · NHLBI · UNIVERSITY OF IOWA · PI CARTER, BARRY L · 2009 to 2013
$4.7MA collaborative model to improve BP control and minimize racial disparities--DCCR01HL091843 · NHLBI · UNIVERSITY OF IOWA · PI FOSTER, ERIC D. · 2009 to 2013
$3.6MNHLBI NIH HHS R01 HL091841NHLBI NIH HHS R01HL091841NHLBI NIH HHS R01 HL091843NHLBI NIH HHS R01HL091843NHLBI NIH HHS R18 HL116259
Abstract
backgroundThe purpose of this study was to evaluate if a physician/pharmacist collaborative model would be implemented as determined by improved blood pressure (BP) control in primary care medical offices with diverse geographic and patient characteristics and whether long-term BP control could be sustained. METHODS AND
resultsProspective, cluster-randomized trial of 32 primary care offices stratified and randomized to control, 9-month intervention (brief), and 24-month intervention (sustained). We enrolled 625 subjects with uncontrolled hypertension; 54% from racial/ethnic minority groups and 50% with diabetes mellitus or chronic kidney disease. The primary outcome of BP control at 9 months was 43% in intervention offices (n=401) compared with 34% in the control group (n=224; adjusted odds ratio, 1.57 [95% confidence interval, 0.99-2.50]; P=0.059). The adjusted difference in mean systolic/diastolic BP between the intervention and control groups for all subjects at 9 months was -6.1/-2.9 mm Hg (P=0.002 and P=0.005, respectively), and it was -6.4/-2.9 mm Hg (P=0.009 and P=0.044, respectively) in subjects from racial or ethnic minorities. BP control and mean BP were significantly improved in subjects from racial minorities in intervention offices at 18 and 24 months (P=0.048 to P<0.001) compared with the control group.
conclusionsAlthough the results of the primary outcome (BP control) were negative, the key secondary end point (mean BP) was significantly improved in the intervention group. Thus, the findings for secondary end points suggest that team-based care using clinical pharmacists was implemented in diverse primary care offices and BP was reduced in subjects from racial minority groups. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00935077.
Indexed as
PharmacistsAgedAntihypertensive AgentsCooperative BehaviorFemaleHumansHypertensionMaleMiddle AgedMinority GroupsProspective StudiesAntihypertensive Agentshypertensionpatient care teampharmacists
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT00935077ClinicalTrials.gov
NCT02919033ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.