ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2015
The Co-4 locus on chromosome Pv08 contains a unique cluster of 18 COK-4 genes and is regulated by immune response in common bean.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 47 citations in OpenAlex.
- Beyond the Halo: Molecular Mechanisms and Ecological Aspects of the Infection Strategy ofInternational journal of molecular sciences · 2026Review
- Fine Mapping of thePlants (Basel, Switzerland) · 2026Article
- Mapping of quantitative trait locus for resistance to anthracnose in a population derived from genotypes PI 527538 and Ervilha of common bean.Frontiers in plant science · 2025Article
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- The Kirkhouse Trust: Successes and Challenges in Twenty Years of Supporting Independent, Contemporary Grain Legume Breeding Projects in India and African Countries.Plants (Basel, Switzerland) · 2024Review
- Fine mapping of a new common bean anthracnose resistance gene (Co-18) to the proximal end of Pv10 in Indian landrace KRC-5.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Automating high-throughput screening for anthracnose resistance in common bean using allele specific PCR.Plant methods · 2023Article
- Genome-wide association analysis of anthracnose resistance in the Yellow Bean Collection of Common Bean.PloS one · 2023Article
- Article
- Phaseolus vulgaris-Colletotrichum lindemuthianum Pathosystem in the Post-Genomic Era: An Update.Current microbiology · 2022Review
- Protein Kinase Signaling Pathways in Plant-Frontiers in plant science · 2021Review
- QTL mapping of post-processing color retention in two black bean populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- North-Western Himalayan Common Beans: Population Structure and Mapping of Quantitative Anthracnose Resistance Through Genome Wide Association Study.Frontiers in plant science · 2020Article
- The common bean COK-4 and the Arabidopsis FER kinase domain share similar functions in plant growth and defence.Molecular plant pathology · 2018Article
- Article
- Genome-Wide Association Study of Anthracnose Resistance in Andean Beans (Phaseolus vulgaris).PloS one · 2016Article
- Transcriptome Profiling of the Phaseolus vulgaris - Colletotrichum lindemuthianum Pathosystem.PloS one · 2016Article
- Candidate Gene Identification with SNP Marker-Based Fine Mapping of Anthracnose Resistance Gene Co-4 in Common Bean.PloS one · 2015Article
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Authors and funding
3 authors at 2 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
key messageThe common bean locus Co - 4, traditionally referred to as an anthracnose-resistant gene, contains a cluster of predicted receptor-like kinases (COK-4 and CrRLK1-like), and at least two of these kinases are co-regulated with the plant's basal immunity. Genetic resistance to anthracnose, caused by the fungus Colletotrichum lindemuthianum (Sacc. and Magnus) Briosi and Cavara, is conferred by major loci throughout the Phaseolus vulgaris genome, named Co. The complex Co-4 locus was previously reported to have several copies of the COK-4 gene that is predicted to code for a receptor-like kinase (RLK). In general, plant RLKs are involved in pathogen perception and signal transduction; however, the molecular function of COK-4 remains elusive. Using newly identified molecular markers (PvTA25 and PvSNPCOK-4), the SAS13 marker, COK-4 sequences and phylogeny, and the recently released bean genome sequence, we determined the most probable boundaries of the Co-4 locus: a 325-Kbp region on chromosome Pv08. Out of the 49 predicted transcripts in that region, 24 encode for putative RLKs (including 18 COK-4 copies) with high similarity to members of the Catharanthus roseus RLK1-like (CrRLK1L) protein family from different plant species, including the well-described FERONIA (FER) and ANXUR. We also determined that two RLK-coding genes in the Co-4 locus (COK-4-3 and FER-like) are transcriptionally regulated when bean plants are challenged with the flg22 peptide, a commonly used elicitor of plant immunity, or the bacterium Pseudomonas syringae pv. phaseolicola, the causal agent of halo blight. While COK-4-3 is activated during immune response, FER-like is downregulated suggesting that these genes could play a role in plant responses to biotic stress. These results highlight the importance of dissecting the regulation and molecular function of individual genes within each locus, traditionally referred to as resistance gene based on genetic segregation analysis.
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