ArticleJournal of exposure science & environmental epidemiology
The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures.
Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03225534 (Project 500 CHILD Study), which is not on this map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Project 500 CHILD Study
Who cites it
33 citing papers in PubMed, 72 citations in OpenAlex.
- Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study.PloS one · 2019Trial
- Integrating omics and artificial intelligence in pediatric environmental health: tools, challenges, and cohort-based insights.Pediatric research · 2026Review
- Organophosphate ester flame retardants and plasticizers in house dust and Child Behavior Checklist outcomes: A nested study in the Canadian CHILD Birth Cohort.Journal of exposure science & environmental epidemiology · 2026Article
- Child Health Research Using linked Multi-domain Canadian Administrative Data: A Scoping Review.International journal of population data science · 2026Article
- RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood.Genome biology · 2025Article
- Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice.BMC medicine · 2025Article
- Determining the interplay of prenatal parental BMI in shaping child BMI trajectories: the CHILD Cohort Study.International journal of obesity (2005) · 2025Article
- Protocol: the International Milk Composition (IMiC) Consortium - a harmonized secondary analysis of human milk from four studies.Frontiers in nutrition · 2025Article
- Human milk feeding practices and serum immune profiles of one-year-old infants in the CHILD birth cohort study.The American journal of clinical nutrition · 2025Observational
- From Fetus to Eight: the CHILD Cohort Study.American journal of epidemiology · 2024Article
- Behavioral observation and assessment protocol for language and social-emotional development study in children aged 0-6: the Chinese baby connectome project.BMC psychology · 2024Article
- The Environmental Exposures in Lebanese Infants (EELI) birth cohort: an investigation into the Developmental Origins of Health and Diseases (DOHaD).International journal of environmental health research · 2024Article
- Organophosphate ester flame retardants and plasticizers in house dust and mental health outcomes among Canadian mothers: A nested prospective cohort study in CHILD.Environmental research · 2024Article
- Data resource profile: a nationally representative linked pregnancy cohort in Canada integrating clinical, social, and environmental data.International journal of population data science · 2023Article
- COVID-19 and the impacts on youth mental health: emerging evidence from longitudinal studies.Canadian journal of public health = Revue canadienne de sante publique · 2022Article
- Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm.Journal of personalized medicine · 2022Review
- Archive for Research in Child Health (ARCH) and Baby Gut: Study Protocol for a Remote, Prospective, Longitudinal Pregnancy and Birth Cohort to Address Microbiota Development and Child Health.Methods and protocols · 2021Article
- A rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization.Cell reports. Medicine · 2021Article
- Home environment allergen exposure scale in older adult cohort with asthma.Canadian journal of public health = Revue canadienne de sante publique · 2021Article
- Human milk fungi: environmental determinants and inter-kingdom associations with milk bacteria in the CHILD Cohort Study.BMC microbiology · 2020Article
Corrections and comments
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Authors and funding
22 authors at 10 institutions in 4 countries.
Funding
Abstract
The Canadian Healthy Infant Longitudinal Development birth cohort was designed to elucidate interactions between environment and genetics underlying development of asthma and allergy. Over 3600 pregnant mothers were recruited from the general population in four provinces with diverse environments. The child is followed to age 5 years, with prospective characterization of diverse exposures during this critical period. Key exposure domains include indoor and outdoor air pollutants, inhalation, ingestion and dermal uptake of chemicals, mold, dampness, biological allergens, pets and pests, housing structure, and living behavior, together with infections, nutrition, psychosocial environment, and medications. Assessments of early life exposures are focused on those linked to inflammatory responses driven by the acquired and innate immune systems. Mothers complete extensive environmental questionnaires including time-activity behavior at recruitment and when the child is 3, 6, 12, 24, 30, 36, 48, and 60 months old. House dust collected during a thorough home assessment at 3-4 months, and biological specimens obtained for multiple exposure-related measurements, are archived for analyses. Geo-locations of homes and daycares and land-use regression for estimating traffic-related air pollution complement time-activity-behavior data to provide comprehensive individual exposure profiles. Several analytical frameworks are proposed to address the many interacting exposure variables and potential issues of co-linearity in this complex data set.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.