ArticleAmerican journal of physiology. Endocrinology and metabolism2015
Formate metabolism in fetal and neonatal sheep.
Article in American journal of physiology. Endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Key biochemical pathways during pregnancy in livestock: mechanisms regulating uterine and placental development and function.Reproduction & fertility · 2025Review
- D-glucaro-1,4-lactone alleviates acetaminophen-induced hepatotoxicity in mice via modulating gut microbiota and metabolites associated withFrontiers in pharmacology · 2025Article
- Predictive blood biomarkers of sheep pregnancy and litter size.Scientific reports · 2022Article
- Nutrient sources differ in the fertilised eggs of two divergent broiler lines selected for meat ultimate pH.Scientific reports · 2022Article
- Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities.Frontiers in neuroscience · 2022Article
- One-Carbon Metabolism and Development of the Conceptus During Pregnancy: Lessons from Studies with Sheep and Pigs.Advances in experimental medicine and biology · 2021Article
- Maternal Supplementation with Dietary Betaine during Gestation to Improve Twin Lamb Survival.Animals : an open access journal from MDPI · 2020Article
- Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics.Metabolites · 2020Article
- Article
- A Review of the Effect of Formic Acid and Its Salts on the Gastrointestinal Microbiota and Performance of Pigs.Animals : an open access journal from MDPI · 2020Review
- Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers.The Journal of nutrition · 2020Article
- Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Formate metabolism in health and disease.Molecular metabolism · 2020Review
- Formate concentrations in maternal plasma during pregnancy and in cord blood in a cohort of pregnant Canadian women: relations to genetic polymorphisms and plasma metabolites.The American journal of clinical nutrition · 2019Article
- Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor.Archives of medical science : AMS · 2019Article
- Mechanisms for the establishment and maintenance of pregnancy: synergies from scientific collaborations.Biology of reproduction · 2018Review
- Lifestyle, metabolite, and genetic determinants of formate concentrations in a cross-sectional study in young, healthy adults.The American journal of clinical nutrition · 2018Observational
- Global Metabolomics of the Placenta Reveals Distinct Metabolic Profiles between Maternal and Fetal Placental Tissues Following Delivery in Non-Labored Women.Metabolites · 2018Article
- One carbon metabolism in pregnancy: Impact on maternal, fetal and neonatal health.Molecular and cellular endocrinology · 2016Review
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
By virtue of its role in nucleotide synthesis, as well as the provision of methyl groups for vital methylation reactions, one-carbon metabolism plays a crucial role in growth and development. Formate, a critical albeit neglected component of one-carbon metabolism, occurs extracellularly and may provide insights into cellular events. We examined formate metabolism in chronically cannulated fetal sheep (gestation days 119-121, equivalent to mid-third trimester in humans) and in their mothers as well as in normal full-term lambs. Plasma formate levels were much higher in fetal lamb plasma and in amniotic fluid (191 ± 62 and 296 ± 154 μM, respectively) than in maternal plasma (33 ± 13 μM). Measurements of folate, vitamin B12, and homocysteine showed that these high formate levels could not be due to vitamin deficiencies. Elevated formate levels were also found in newborn lambs and persisted to about 8 wk of age. Formate was also found in sheep milk. Potential precursors of one-carbon groups were also measured in fetal and maternal plasma and in amniotic fluid. There were very high concentrations of serine in the fetus (∼1.6 mM in plasma and 3.5 mM in the amniotic fluid) compared with maternal plasma (0.19 mM), suggesting increased production of formate; however, we cannot rule out decreased formate utilization. Dimethylglycine, a choline metabolite, was also 30 times higher in the fetus than in the mother.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.