Evidence map›Paper›PMID 25805106›Full record

ArticleActa biomaterialia2015

Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment.

Yu-Ru Shih, Ameya Phadke, Tomonori Yamaguchi, Heemin Kang, Nozomu Inoue, Koichi Masuda, Shyni Varghese

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Static and Dynamic Biomaterial Engineering for Cell Modulation.Nanomaterials (Basel, Switzerland) · 2022
    Review
  3. In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.Advanced materials (Deerfield Beach, Fla.) · 2020
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu-Ru ShihDepartment of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
Ameya PhadkeDepartment of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
Tomonori YamaguchiDepartment of Orthopaedic Surgery, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Biomedical Engineering, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
Heemin KangDepartment of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
Nozomu InoueDepartment of Biomedical Engineering, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
Koichi MasudaDepartment of Orthopaedic Surgery, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: komasuda@ucsd.edu.
Shyni VargheseDepartment of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: svarghese@ucsd.edu.

Funding

Diversity Supplement -"Bioinspired Synthetic Grafts for Bone Regeneration"R01AR063184 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARGHESE, SHYNI · 2013 to 2017
$1.7M
NIAMS NIH HHS 1 R01 AR063184-01A1NIAMS NIH HHS R01 AR063184
6 · The paper itself

Abstract

Advances in tissue engineering have offered new opportunities to restore anatomically and functionally compromised tissues. Although traditional tissue engineering approaches that utilize biomaterials and cells to create tissue constructs for implantation or biomaterials as a scaffold to deliver cells are promising, strategies that can activate endogenous cells to promote tissue repair are more clinically attractive. Here, we demonstrate that an engineered injectable matrix mimicking a calcium phosphate (CaP)-rich bone-specific microenvironment can recruit endogenous cells to form bone tissues in vivo. Comparison of matrix alone with that of bone marrow-soaked or bFGF-soaked matrix demonstrates similar extent of neo-bone formation and bridging of decorticated transverse processes in a posterolateral lumbar fusion rat model. Synthetic biomaterials that stimulate endogenous cells without the need for biologics to assist tissue repair could circumvent limitations associated with conventional tissue engineering approaches, including ex vivo cell processing and laborious efforts, thereby accelerating the translational aspects of regenerative medicine.

Indexed as

Tissue ScaffoldsAnimalsBiomimetic MaterialsBone DevelopmentBone MatrixBone SubstitutesBone TransplantationCalcium PhosphatesEquipment DesignEquipment Failure AnalysisFemoral FracturesMaleMaterials TestingOsteogenesisRatsRats, NudeBone Substitutescalcium phosphateCalcium PhosphatesBiomimetic materialsBiomineralizationBone graftsPosterolateral fusionSpine

Identifiers

PMID25805106
PMCPMC5644488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.