Evidence map›Paper›PMID 25804410›Full record

ArticleScientific reports2015

Investigating a new neuromodulation treatment for brain disorders using synchronized activation of multimodal pathways.

Craig D Markovitz, Benjamin T Smith, Cory D Gloeckner, Hubert H Lim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Craig D MarkovitzDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN USA.
Benjamin T SmithDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN USA.
Cory D GloecknerDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN USA.
Hubert H Lim1] Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN USA [2] Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, MN USA [3] Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN USA.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Electrophysiological mapping of corticocollicular projections involved with tonotR03DC011589 · NIDCD · UNIVERSITY OF MINNESOTA · PI LIM, HUBERT HYUNGIL · 2011 to 2013
$424k
NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1TR000114NIDCD NIH HHS R03 DC011589NIDCD NIH HHS R03DC011589
6 · The paper itself

Abstract

Neuromodulation is an increasingly accepted treatment for neurological and psychiatric disorders but is limited by its invasiveness or its inability to target deep brain structures using noninvasive techniques. We propose a new concept called Multimodal Synchronization Therapy (mSync) for achieving targeted activation of the brain via noninvasive and precisely timed activation of auditory, visual, somatosensory, motor, cognitive, and limbic pathways. In this initial study in guinea pigs, we investigated mSync using combined activation of just the auditory and somatosensory pathways, which induced differential and timing dependent plasticity in neural firing within deep brain and cortical regions of the auditory system. Furthermore, by varying the location of somatosensory stimulation across the body, we increased or decreased spiking activity across different neurons. These encouraging results demonstrate the feasibility of systematically modulating the brain using mSync. Considering that hearing disorders such as tinnitus and hyperacusis have been linked to abnormal and hyperactive firing patterns within the auditory system, these results open up the possibility for using mSync to decrease this pathological activity by varying stimulation parameters. Incorporating multiple types of pathways beyond just auditory and somatosensory inputs and using other activation patterns may enable treatment of various brain disorders.

Indexed as

Electric StimulationAcoustic StimulationAnimalsBrainBrain DiseasesCombined Modality TherapyGuinea PigsHumansNeuronal PlasticityNeuronsNeurotransmitter AgentsSomatosensory CortexTinnitusNeurotransmitter Agents

Identifiers

PMID25804410
PMCPMC4372796
OpenAlexW1976079786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.