Evidence map›Paper›PMID 25804268›Full record

Trial reportEuropean journal of clinical nutrition2015

Omega-3 fatty acids in the management of autism spectrum disorders: findings from an open-label pilot study in Singapore.

Y P Ooi, S-J Weng, L Y Jang, L Low, J Seah, S Teo, R P Ang, C G Lim, A Liew, D S Fung and 1 more

Open access · bronzeAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 7 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 7 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Nutraceuticals in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2024
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  11. Effects ofNutrients · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Y P Ooi1] Clinical Psychology and Psychotherapy, Department of Psychology, University of Basel, Basel, Switzerland [2] Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore [3] Child Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore.
S-J Weng1] Child Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore [2] DUKE-NUS Graduate Medical School Singapore, Singapore, Singapore.
L Y JangChild Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore.
L LowChild Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore.
J SeahChild Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore.
S TeoChild Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore.
R P AngNational Institute of Education, Nanyang Technological University, Singapore, Singapore.
C G Lim1] Child Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore [2] DUKE-NUS Graduate Medical School Singapore, Singapore, Singapore.
A LiewChild Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore.
D S Fung1] Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore [2] Child Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore [3] DUKE-NUS Graduate Medical School Singapore, Singapore, Singapore.
M SungChild Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore.
Health Promotion Board · SGNanyang Technological University · SGDuke-NUS Medical School · SGNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of this open-label trial was to examine the efficacy and safety of a 12-week omega-3 fatty acids supplementation among children suffering with Autism Spectrum Disorders (ASD). A total of 41 children and adolescents aged 7-18 years (36 boys, 5 girls; mean age = 11.66, s.d. = 3.05) diagnosed with ASD participated in the study. At post-treatment, participants showed significant improvements on all subscales of the Social Responsiveness Scale (P < 0.01) and the Social and Attention Problems syndrome scales of the Child Behavior Checklist (P < 0.05). Blood fatty acid levels were significantly correlated with changes in the core symptoms of ASD. Baseline levels of blood fatty acid levels were also predictive of response to the omega-3 treatment. Omega-3 fatty acids supplementation was well-tolerated and did not cause any serious side effects. Our findings lend some preliminary support for the use of omega-3 fatty acids supplementation in addressing ASD. Future randomized controlled trials of omega-3 fatty acids in ASD with blood fatty acid measurements with a larger sample and longer follow-up period is warranted.

Indexed as

Dietary SupplementsAdolescentAttentionAutism Spectrum DisorderBehavior Rating ScaleChildFatty AcidsFatty Acids, Omega-3FemaleHumansMalePilot ProjectsSingaporeTreatment OutcomeFatty AcidsFatty Acids, Omega-3

Identifiers

PMID25804268
OpenAlexW2055252624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.