Evidence map›Paper›PMID 25803824›Full record

ReviewNeuropediatrics2015

Applications of optical coherence tomography in pediatric clinical neuroscience.

Robert A Avery, Raneem D Rajjoub, Carmelina Trimboli-Heidler, Amy T Waldman

Open access · greenAbstract readReview
In one paragraph

Review in Neuropediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Characterising microstructural retinal changes in children with inherited retinal dystrophies - a retrospective observational cross-sectional study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Review
  13. Pediatric Optic Neuritis: What Is New.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2017
    Review
  14. Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2017
    Review
  15. [Strabologic and neuro-ophthamologic aspects of childhood cancer].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2016
    Review
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Robert A AveryThe Gilbert Family Neurofibromatosis Institute, Children's National Health System, Washington, District of Columbia, United States.
Raneem D RajjoubGeorge Washington University School of Medicine, Washington, District of Columbia, United States.
Carmelina Trimboli-HeidlerThe Gilbert Family Neurofibromatosis Institute, Children's National Health System, Washington, District of Columbia, United States.
Amy T WaldmanDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
Children's National · USChildren's Hospital of Philadelphia · USGeorge Washington University · US

Funding

Visual outcome measures in children with optic Pathway gliomasK23EY022673 · NEI · CHILDREN'S RESEARCH INSTITUTE · PI AVERY, ROBERT ANDREW · 2012 to 2016
$1.1M
Development of visual and neurologic outcome measures in pediatric MSK23NS069806 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI WALDMAN, AMY TARA · 2012 to 2016
$924k
NEI NIH HHS K23 EY022673NEI NIH HHS K23-EY022673NINDS NIH HHS K23 NS069806NINDS NIH HHS K23-NS069806
6 · The paper itself

Abstract

For nearly two centuries, the ophthalmoscope has permitted examination of the retina and optic nerve-the only axons directly visualized by the physician. The retinal ganglion cells project their axons, which travel along the innermost retina to form the optic nerve, marking the beginning of the anterior visual pathway. Both the structure and function of the visual pathway are essential components of the neurologic examination as it can be involved in numerous acquired, congenital and genetic central nervous system conditions. The development of optical coherence tomography now permits the pediatric neuroscientist to visualize and quantify the optic nerve and retinal layers with unprecedented resolution. As optical coherence tomography becomes more accessible and integrated into research and clinical care, the pediatric neuroscientist may have the opportunity to utilize and/or interpret results from this device. This review describes the basic technical features of optical coherence tomography and highlights its potential clinical and research applications in pediatric clinical neuroscience including optic nerve swelling, optic neuritis, tumors of the visual pathway, vigabatrin toxicity, nystagmus, and neurodegenerative conditions.

Indexed as

Tomography, Optical CoherenceChildChild, PreschoolEye DiseasesHumansNeurologyOptic Nerve DiseasesPediatricsRetinal Diseases

Identifiers

PMID25803824
PMCPMC4436151
OpenAlexW2037363243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.