Evidence map›Paper›PMID 25803577›Full record

Trial reportPloS one2015

Safety and efficacy of at-home robotic locomotion therapy in individuals with chronic incomplete spinal cord injury: a prospective, pre-post intervention, proof-of-concept study.

Rüdiger Rupp, Daniel Schließmann, Harry Plewa, Christian Schuld, Hans Jürgen Gerner, Norbert Weidner, Eberhard P Hofer, Markus Knestel

Erratum issuedOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rüdiger RuppHeidelberg University Hospital, Spinal Cord Injury Center, Heidelberg, Germany.
Daniel SchließmannHeidelberg University Hospital, Spinal Cord Injury Center, Heidelberg, Germany.
Harry PlewaHeidelberg University Hospital, Spinal Cord Injury Center, Heidelberg, Germany.
Christian SchuldHeidelberg University Hospital, Spinal Cord Injury Center, Heidelberg, Germany.
Hans Jürgen GernerHeidelberg University Hospital, Spinal Cord Injury Center, Heidelberg, Germany.
Norbert WeidnerHeidelberg University Hospital, Spinal Cord Injury Center, Heidelberg, Germany.
Eberhard P HoferUlm University, Institute of Measurement, Control and Microtechnology, Ulm, Germany.
Markus KnestelUlm University, Institute of Measurement, Control and Microtechnology, Ulm, Germany.
Heidelberg University · DEUniversity Hospital Heidelberg · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe compact Motorized orthosis for home rehabilitation of Gait (MoreGait) was developed for continuation of locomotion training at home. MoreGait generates afferent stimuli of walking with the user in a semi-supine position and provides feedback about deviations from the reference walking pattern.

objectiveProspective, pre-post intervention, proof-of-concept study to test the feasibility of an unsupervised home-based application of five MoreGait prototypes in subjects with incomplete spinal cord injury (iSCI).

methodsTwenty-five (5 tetraplegia, 20 paraplegia) participants with chronic (mean time since injury: 5.8 ± 5.4 (standard deviation, SD) years) sensorimotor iSCI (7 ASIA Impairment Scale (AIS) C, 18 AIS D; Walking Index for Spinal Cord Injury (WISCI II): Interquartile range 9 to 16) completed the training (45 minutes / day, at least 4 days / week, 8 weeks). Baseline status was documented 4 and 2 weeks before and at training onset. Training effects were assessed after 4 and 8 weeks of therapy.

resultsAfter therapy, 9 of 25 study participants improved with respect to the dependency on walking aids assessed by the WISCI II. For all individuals, the short-distance walking velocity measured by the 10-Meter Walk Test showed significant improvements compared to baseline (100%) for both self-selected (Mean 139.4% ± 35.5% (SD)) and maximum (Mean 143.1% ± 40.6% (SD)) speed conditions as well as the endurance estimated with the six-minute walk test (Mean 166.6% ± 72.1% (SD)). One device-related adverse event (pressure sore on the big toe) occurred in over 800 training sessions.

conclusionsHome-based robotic locomotion training with MoreGait is feasible and safe. The magnitude of functional improvements achieved by MoreGait in individuals with iSCI is well within the range of complex locomotion robots used in hospitals. Thus, unsupervised MoreGait training potentially represents an option to prolong effective training aiming at recovery of locomotor function beyond in-patient rehabilitation.

trial registrationGerman Clinical Trials Register (DKRS) DRKS00005587.

Indexed as

Home Care ServicesAdultExercise TherapyFemaleGait Disorders, NeurologicHumansLocomotionMaleMiddle AgedParaplegiaProspective StudiesQuadriplegiaRecovery of FunctionRoboticsSpinal Cord Injuries

Identifiers

PMID25803577
PMCPMC4372343
OpenAlexW2018677793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.