ArticleNature chemistry2015
Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose.
Article in Nature chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed.
- Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers.Nature communications · 2026Article
- Molecular Tweezers for Biomimetic Recognition of Carbohydrates.Chembiochem : a European journal of chemical biology · 2025Review
- Design of an abiotic unimolecular three-helix bundle.Chemical science · 2025Article
- Synthetic molecular cage receptors for carbohydrate recognition.Nature reviews. Chemistry · 2025Review
- Light-Mediated Interconversion between a Foldamer and a Self-Replicator.Journal of the American Chemical Society · 2024Article
- Discovery of selective monosaccharide receptorsOrganic & biomolecular chemistry · 2024Article
- Visible-Light Driven Control Over Triply and Quadruply Hydrogen-Bonded Supramolecular Assemblies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Complexation-driven assembly of imine-linked helical receptors showing adaptive folding and temperature-dependent guest selection.Nature communications · 2024Article
- Comparative Study of Molecular Mechanics Force Fields for β-Peptidic Foldamers: Folding and Self-Association.Journal of chemical information and modeling · 2023Article
- High-affinity single and double helical pseudofoldaxanes with cationic guests.Chemical science · 2023Article
- Recognition Site Modifiable Macrocycle: Synthesis, Functional Group Variation and Structural Inspection.Molecules (Basel, Switzerland) · 2023Article
- De novo design of discrete, stable 3Nature · 2022Article
- Generalizing the Aromatic δ-Amino Acid Foldamer Helix.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly.Nature communications · 2022Article
- Review
- A Water Soluble PdChemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature.Molecules (Basel, Switzerland) · 2021Review
- A versatile living polymerization method for aromatic amides.Nature chemistry · 2021Article
- Binding modes of methyl α-d-glucopyranoside to an artificial receptor in crystalline complexes.RSC advances · 2021Article
- An Octa-Urea [PdChemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ab initio design of synthetic molecular receptors for a specific biomolecular guest remains an elusive objective, particularly for targets such as monosaccharides, which have very close structural analogues. Here we report a powerful approach to produce receptors with very high selectivity for specific monosaccharides and, as a demonstration, we develop a foldamer that selectively encapsulates fructose. The approach uses an iterative design process that exploits the modular structure of folded synthetic oligomer sequences in conjunction with molecular modelling and structural characterization to inform subsequent refinements. Starting from a first-principles design taking size, shape and hydrogen-bonding ability into account and using the high predictability of aromatic oligoamide foldamer conformations and their propensity to crystallize, a sequence that binds to β-D-fructopyranose in organic solvents with atomic-scale complementarity was obtained in just a few iterative modifications. This scheme, which mimics the adaptable construction of biopolymers from a limited number of monomer units, provides a general protocol for the development of selective receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.