ArticlePloS one2015
The functions of atrial strands interdigitating with and penetrating into sinoatrial node: a theoretical study of the problem.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis.Journal of cardiovascular development and disease · 2021Review
- Development of the cardiac pacemaker.Cellular and molecular life sciences : CMLS · 2017Review
- Computational assessment of the functional role of sinoatrial node exit pathways in the human heart.PloS one · 2017Article
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Authors and funding
2 authors.
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Abstract
The sinoatrial node (SAN)-atrium system is closely involved with the activity of heart beating. The impulse propagation and phase-locking behaviors of this system are of theoretical interest. Some experiments have revealed that atrial strands (ASs) interdigitate with and penetrate into the SAN, whereby the SAN-atrium system works as a complex network. In this study, the functions of ASs are numerically investigated using realistic cardiac models. The results indicate that the ASs penetrating into the central region of the SAN play a major role in propagating excitation into the atrium. This is because the threshold SAN-AS coupling for an AS to function as an alternative path for propagation is lower at the center than at the periphery. However, ASs penetrating into the peripheral region have a great effect in terms of enlarging the 1:1 entrainment range of the SAN because the automaticity of the SAN is evidently reduced by ASs. Moreover, an analytical formula for approximating the enlargement of the 1:1 range is derived.
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