Evidence map›Paper›PMID 25803373›Full record

ArticleThe West Indian medical journal2014

HIV-1 Antiretroviral Drug Resistance in Pregnant Women in Jamaica: A Preliminary Report.

I I Amarakoon, A Ramkissoon, R Pierre, L M Eyzaguirre, J K Carr, W A Blattner, M E Roye

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The West Indian medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

I I AmarakoonBiotechnology Centre, The University of the West Indies, Kingston 7, Jamaica.
A RamkissoonBiotechnology Centre, The University of the West Indies, Kingston 7, Jamaica.
R PierreDepartment of Child and Adolescent Health, The University of the West Indies, Kingston 7, Jamaica.
L M EyzaguirreInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
J K CarrInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
W A BlattnerDepartment of Child and Adolescent Health, The University of the West Indies, Kingston 7, Jamaica.
M E RoyeBiotechnology Centre, The University of the West Indies, Kingston 7, Jamaica.
University of the West Indies System · JMAlabama College of Osteopathic Medicine · USUniversity of Maryland, Baltimore · US

Funding

UM-IHV AITRP in NigeriaD43TW001041 · FIC · UNIVERSITY OF MARYLAND BALTIMORE · PI CHARURAT, MANHATTAN E · 1998 to 2015
$9.2M
FIC NIH HHS D43 TW001041
6 · The paper itself

Abstract

This preliminary report sought to provide insight into the genetic diversity of human immunodeficiency virus drug resistance (HIVDR) in Jamaica. This was done by investigating the genetic diversity associated with drug resistance in pregnant women living with HIV attending antenatal clinics in Kingston, Jamaica. Blood samples were collected and viral RNA were extracted and analysed. The protease and reverse transcriptase (Pro-RT) genes were amplified using the nested polymerase chain reaction (PCR) method. Polymerase chain reaction amplicons were obtained for nine of 16 patients (56%), of which five (55%) were antiretroviral (ARV) drug naïve and four (45%) were treatment experienced. Three minor protease resistant-conferring mutations (A71AT, A71V, A71T) and five mutations conferring high to low-level resistance (K219EK, T69S, K103S, G190A and K103N) were detected in the RT region. More than 50% of the resistance mutations found were detected in ARV drug naïve individuals, implying that viruses are being transmitted with the ARV resistance. These preliminary results will inform the health practitioners of the level of drug resistance that is being transmitted as well as strengthen the need to initiate a national baseline survey on HIVDR in Jamaica.

Identifiers

PMID25803373
PMCPMC4663965
OpenAlexW1972485287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.