ArticleHigh altitude medicine & biology2015
Hypobaric hypoxia induces depression-like behavior in female Sprague-Dawley rats, but not in males.
Article in High altitude medicine & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Electroconvulsive therapy (ECT) increases serum hypoxia‑inducible factor‑1 alpha (HIF- 1α) in depressed patients.Psychopharmacology · 2026Article
- Hypoxia Disrupted Serotonin Levels in the Prefrontal Cortex and Striatum, Leading to Depression-like Behavior.Biology · 2025Article
- A preliminary exploration of establishing a mice model of hypoxic training.Scientific reports · 2025Article
- Nocturnal hypoxia in patients with sleep disorders: exploring its role as a mediator between neurotic personality traits and psychological symptoms.Frontiers in psychiatry · 2024Article
- Exploring the Role of Drug Repurposing in Bridging the Hypoxia-Depression Connection.Membranes · 2023Article
- Sestrin-2 and hypoxia-ınducible factor-1 alpha levels in major depressive disorder and its subtypes.Psychopharmacology · 2023Article
- Disparities in the prevalence of screened depression at different altitudes in Peru: A retrospective analysis of the ENDES 2019.PloS one · 2022Article
- Women's mood at high altitude. sexual dimorphism in hypoxic stress modulation by the tryptophan-melatonin axis.Frontiers in physiology · 2022Review
- An Inexpensive Open-Source Chamber for Controlled Hypoxia/Hyperoxia Exposure.Frontiers in physiology · 2022Article
- Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression.Psychopharmacology · 2021Article
- Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression.International journal of molecular sciences · 2021Article
- The Association Between Hypoxia Improvement and Electroconvulsive Therapy for Major Depressive Disorder.Neuropsychiatric disease and treatment · 2021Article
- Oxygen Enrichment Ameliorates Cardiorespiratory Alterations Induced by Chronic High-Altitude Hypoxia in Rats.Frontiers in physiology · 2020Article
- Brain diseases in changing climate.Environmental research · 2019Review
- Cerebral bioenergetic differences measured by phosphorus-31 magnetic resonance spectroscopy between bipolar disorder and healthy subjects living in two different regions suggesting possible effects of altitude.Psychiatry and clinical neurosciences · 2019Article
- Creatine for the Treatment of Depression.Biomolecules · 2019Review
- Association between altitude, prescription opioid misuse, and fatal overdoses.Addictive behaviors reports · 2019Article
- Injury-Related Deaths according to Environmental, Demographic, and Lifestyle Factors.Journal of environmental and public health · 2019Article
- Modeling the effects of atmospheric pressure on suicide rates in the USA using geographically weighted regression.PloS one · 2018Article
- Animal models to improve our understanding and treatment of suicidal behavior.Translational psychiatry · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Rates of depression and suicide are higher in people living at altitude, and in those with chronic hypoxic disorders like asthma, chronic obstructive pulmonary disorder (COPD), and smoking. Living at altitude exposes people to hypobaric hypoxia, which can lower rat brain serotonin levels, and impair brain bioenergetics in both humans and rats. We therefore examined the effect of hypobaric hypoxia on depression-like behavior in rats. After a week of housing at simulated altitudes of 20,000 ft, 10,000 ft, or sea level, or at local conditions of 4500 ft (Salt Lake City, UT), Sprague Dawley rats were tested for depression-like behavior in the forced swim test (FST). Time spent swimming, climbing, or immobile, and latency to immobility were measured. Female rats housed at altitude display more depression-like behavior in the FST, with significantly more immobility, less swimming, and lower latency to immobility than those at sea level. In contrast, males in all four altitude groups were similar in their FST behavior. Locomotor behavior in the open field test did not change with altitude, thus validating immobility in the FST as depression-like behavior. Hypobaric hypoxia exposure therefore induces depression-like behavior in female rats, but not in males.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.