ArticleProceedings of the National Academy of Sciences of the United States of America1985
Structure of a gene for the human epidermal 67-kDa keratin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study.PloS one · 2023Article
- Keratin 1 plays a critical role in golgi localization of core 2 N-acetylglucosaminyltransferase M via interaction with its cytoplasmic tail.The Journal of biological chemistry · 2015Article
- Biotechnological Aspects and Perspective of Microbial Keratinase Production.BioMed research international · 2015Review
- In vitro human keratinocyte migration rates are associated with SNPs in the KRT1 interval.PloS one · 2007Article
- C/EBPbeta modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression.Molecular and cellular biology · 1999Article
- Cyclic ichthyosis with epidermolytic hyperkeratosis: A phenotype conferred by mutations in the 2B domain of keratin K1.American journal of human genetics · 1999Article
- Intermediate filament expression in prostate cancer.Cancer metastasis reviews · 1996Review
- The function of intermediate filaments in cell shape and cytoskeletal integrity.The Journal of cell biology · 1996Article
- Differential expression of CRABP II, psoriasin and cytokeratin 1 mRNA in human skin diseases.Archives of dermatological research · 1996Article
- Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA.The EMBO journal · 1996Article
- Tissue-specific in vivo protein-DNA interactions at the promoter region of the Xenopus 63 kDa keratin gene during metamorphosis.Nucleic acids research · 1995Article
- Isolation and characterization of sulfur globule proteins from Chromatium vinosum and Thiocapsa roseopersicina.Archives of microbiology · 1995Article
- Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.The EMBO journal · 1994Article
- Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity.The Journal of clinical investigation · 1994Article
- A review of intermediate filament biology and their use in pathologic diagnosis.Molecular biology reports · 1994Review
- Ectopic synthesis of epidermal cytokeratins in pancreatic islet cells of transgenic mice interferes with cytoskeletal order and insulin production.The Journal of cell biology · 1993Article
- Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Transcription factor AP2 and its role in epidermal-specific gene expression.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Structure of an invertebrate gene encoding cytoplasmic intermediate filament (IF) proteins: implications for the origin and the diversification of IF proteins.The EMBO journal · 1990Article
- Epidermal differentiation: the bare essentials.The Journal of cell biology · 1990Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the structure and nucleotide sequence of a gene encoding the human epidermal 67-kDa keratin. Three genomic clones were isolated from a lambda Charon 4A human genomic library by hybridization to a specific cDNA probe. One clone of 12.3 kilobase pairs was shown by R-loop, DNA sequence, and primer-extension analyses to encode an entire gene of about 6.25 kilobase pairs. Of eight identified introns, seven are located within the region that encodes the central coiled-coil alpha-helical domain of the protein. Except for one intron located at the end of the region encoding this domain, these do not delineate apparent structural subdomains. The positions of five of the introns exactly coincide with the positions of introns previously reported in the hamster gene for the intermediate filament protein vimentin [Quax, W., Egberts, W.V., Hendricks, W., Quax-Jeuken, Y. & Bloemandal, H. (1983) Cell 35, 215-233]. These findings suggest that the human 67-kDa keratin and vimentin genes arose from a common ancestral gene.
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