ArticleEnvironmental health perspectives2015
Obesogens beyond Vertebrates: Lipid Perturbation by Tributyltin in the Crustacean Daphnia magna.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 105 citations in OpenAlex.
- From Gut to Brain: Glyphosate and Triclosan Impair Microbiome Composition, Neuroactive Metabolites, and Cognitive and Ecological Fitness inEnvironmental science & technology · 2026Article
- Stimulated Raman Scattering (SRS) Microscopy Enables Visualization and Quantification of Cryoprotective Agent Concentration inAnalytical chemistry · 2025Article
- Environmental Antidepressants Disrupt Metabolic Pathways inMolecules (Basel, Switzerland) · 2025Article
- Lipid metabolism analysis providing insights into nonylphenol multi-toxicity mechanism.iScience · 2023Article
- Article
- Non-target ROIMCR LC-MS analysis of the disruptive effects of TBT over time on the lipidomics of Daphnia magna.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities.Environmental research · 2022Article
- Spatially Mapping the Baseline and Bisphenol-A ExposedMetabolites · 2022Article
- Long Term Exposure to Virgin and Recycled LDPE Microplastics Induced Minor Effects in the Freshwater and Terrestrial CrustaceansPolymers · 2021Article
- Acute toxicity of gold nanoparticles synthesized from macroalga Saccharina japonica towards Daphnia magna.Environmental science and pollution research international · 2020Article
- Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world.Metabolomics : Official journal of the Metabolomic Society · 2020Review
- Role of Obesogens in the Pathogenesis of Obesity.Medicina (Kaunas, Lithuania) · 2019Review
- Tryptophan hydroxylase (TRH) loss of function mutations induce growth and behavioral defects in Daphnia magna.Scientific reports · 2018Article
- Fenoxycarb exposure disrupted the reproductive success of the amphipod Gammarus fossarum with limited effects on the lipid profile.PloS one · 2018Article
- Effects of Organotins on Crustaceans: Update and Perspectives.Frontiers in endocrinology · 2018Review
- Polystyrene nanoplastics inhibit reproduction and induce abnormal embryonic development in the freshwater crustacean Daphnia galeata.Scientific reports · 2017Article
- Article
- Article
- Article
- Mechanisms of Action of Compounds That Enhance Storage Lipid Accumulation in Daphnia magna.Environmental science & technology · 2016Article
Corrections and comments
- Commented on by
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe analysis of obesogenic effects in invertebrates is limited by our poor knowledge of the regulatory pathways of lipid metabolism. Recent data from the crustacean Daphnia magna points to three signaling hormonal pathways related to the molting and reproductive cycles [retinoic X receptor (RXR), juvenile hormone (JH), and ecdysone] as putative targets for exogenous obesogens.
objectiveThe present study addresses the disruptive effects of the model obesogen tributyltin (TBT) on the lipid homeostasis in Daphnia during the molting and reproductive cycle, its genetic control, and health consequences of its disruption.
methodsD. magna individuals were exposed to low and high levels of TBT. Reproductive effects were assessed by Life History analysis methods. Quantitative and qualitative changes in lipid droplets during molting and the reproductive cycle were studied using Nile red staining. Lipid composition and dynamics were analyzed by ultra-performance liquid chromatography coupled to a time-of-flight mass spectrometer. Relative abundances of mRNA from different genes related to RXR, ecdysone, and JH signaling pathways were studied by qRT-PCR. RESULTS AND
conclusionsTBT disrupted the dynamics of neutral lipids, impairing the transfer of triacylglycerols to eggs and hence promoting their accumulation in adult individuals. TBT's disruptive effects translated into a lower fitness for offspring and adults. Co-regulation of gene transcripts suggests that TBT activates the ecdysone, JH, and RXR receptor signaling pathways, presumably through the already proposed interaction with RXR. These findings indicate the presence of obesogenic effects in a nonvertebrate species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.