ArticleMolecular psychiatry2016
Arc expression identifies the lateral amygdala fear memory trace.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- ICER-Controlled inhibitory plasticity of amygdala engram neurons regulates fear memory precision.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Population sparseness determines strength of Hebbian plasticity for maximal memory lifetime in associative networks.PLoS computational biology · 2026Article
- Threat intensity shapes cortical engram architecture supporting remote memory retrieval.Nature communications · 2026Article
- Biophysical mechanisms underlying the generation and maintenance of rule-learning engram.Communications biology · 2026Article
- Monitoring in vivo transcription with synthetic serum markers.Nature communications · 2026Article
- The prefrontal cortex controls memory organization in the hippocampus.Nature neuroscience · 2026Article
- Neural substrate of conditioned stimulus for associative learning in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Writing the Engram: Epigenetic Mechanisms of Memory Allocation.Journal of neurochemistry · 2025Review
- Extended fear learning enhances excitatory and inhibitory synaptic transmission onto amygdala engram cells.Nature communications · 2025Article
- Article
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- Differential Glutamatergic Inputs to Semilunar Granule Cells and Granule Cells Underscore Dentate Gyrus Projection Neuron Diversity.bioRxiv : the preprint server for biology · 2025Article
- Combined loss of brevican, neurocan, tenascin-C and tenascin-R leads to impaired fear retrieval due to perineuronal net loss.Scientific reports · 2025Article
- Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice.Cell · 2025Article
- Theoretical framework for the difference of two negative binomial distributions and its application in comparative analysis of sequencing data.Genome research · 2024Article
- Amygdala neuronal dyshomeostasis via 5-HT receptors mediates mood and cognitive defects in Alzheimer's disease.Aging cell · 2024Article
- Memory allocation at the neuronal and synaptic levels.BMB reports · 2024Review
- Spatially Resolved Transcriptomic Signatures of Hippocampal Subregions andbioRxiv : the preprint server for biology · 2024Article
- Spatially resolved transcriptomic signatures of hippocampal subregions andFrontiers in molecular neuroscience · 2024Article
- Examining memory linking and generalization using scFLARE2, a temporally precise neuronal activity tagging system.Cell reports · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memories are encoded within sparsely distributed neuronal ensembles. However, the defining cellular properties of neurons within a memory trace remain incompletely understood. Using a fluorescence-based Arc reporter, we were able to visually identify the distinct subset of lateral amygdala (LA) neurons activated during auditory fear conditioning. We found that Arc-expressing neurons have enhanced intrinsic excitability and are preferentially recruited into newly encoded memory traces. Furthermore, synaptic potentiation of thalamic inputs to the LA during fear conditioning is learning-specific, postsynaptically mediated and highly localized to Arc-expressing neurons. Taken together, our findings validate the immediate-early gene Arc as a molecular marker for the LA neuronal ensemble recruited during fear learning. Moreover, these results establish a model of fear memory formation in which intrinsic excitability determines neuronal selection, whereas learning-related encoding is governed by synaptic plasticity.
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