ReviewBioMed research international2015
Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties.
Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 304 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
304 citing papers in PubMed, 3 syntheses or guidelines pooled it, 762 citations in OpenAlex.
- Biological Mechanisms of Polyphenols againstInfectious disorders drug targets · 2025Pooled it
- Biomarkers of Berry Intake: Systematic Review Update.Journal of agricultural and food chemistry · 2023Pooled it
- Scientific Evidence for the Beneficial Effects of Dietary Blueberries on Gut Health: A Systematic Review.Molecular nutrition & food research · 2023Pooled it
- Trial
- EAT-Lancet Diet-Associated Serum Metabolites Are Linked to Cardiovascular Disease and Mortality.The Journal of nutrition · 2026Article
- Chronic administration of a calafate (Berberis microphylla) polyphenol-rich extract modulates gut microbiota and metabolic homeostasis associated with thermogenic activation in high-fat diet-fed mice.Journal of physiology and biochemistry · 2026Article
- Foods as Modulators of GLP-1 Secretion.Nutrients · 2026Review
- The Modulating Effects of Fruit and Fruit-Derived Interventions on Arterial Stiffness.Nutrients · 2026Review
- Ultrasound-Assisted Extraction of Bioactive Compounds from Pomegranate Peel Using Vinegar with α-Cyclodextrin as a Green Solvent.Foods (Basel, Switzerland) · 2026Article
- The Triangular Interaction Between Dietary Polyphenols, Gut Microbiota and Type 2 Diabetes.International journal of molecular sciences · 2026Review
- Apple Pomace Fermented with Non-International journal of molecular sciences · 2026Article
- A Systematic Study of the Hepatic-Intestinal First-Pass Effect and Excretion Pathways of Punicalagin Based on UPLC-MS/MS.Molecules (Basel, Switzerland) · 2026Article
- Individual polyphenol metabotypes and longevity: microbial biotransformation and personalized nutrition interventions.Frontiers in nutrition · 2026Article
- Dietary polyphenols and nutritional modulators in glioblastoma: mechanistic promise and translational barriers.Frontiers in nutrition · 2026Review
- Integrating polyphenols and exercise in cancer prevention, treatment, and rehabilitation: cellular and molecular mechanisms linking the injury-recovery-musculoskeletal resilience axis.Frontiers in oncology · 2026Review
- Ruminal Degradation of Puerarin and Its Effects on In Vitro Ruminal Fermentation, Methane Emission, and Microbial Community Structure.Animals : an open access journal from MDPI · 2025Article
- Conventional and Advanced Processing Techniques and Their Effect on the Nutritional Quality and Antinutritional Factors of Pearl Millet Grains: The Impact on Metabolic Health.Antioxidants (Basel, Switzerland) · 2025Review
- Polydatin: A natural compound with multifaceted anticancer properties.Journal of traditional and complementary medicine · 2025Review
- Unlocking Polyphenol Efficacy: The Role of Gut Microbiota in Modulating Bioavailability and Health Effects.Nutrients · 2025Review
- (Poly)phenol-gut microbiota interactions and their impact on human health.Current opinion in clinical nutrition and metabolic care · 2025Review
244 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become bioactive at human body, these polyphenols must undergo diverse intestinal transformations, due to the action of digestive enzymes, but also by the action of microbiota metabolism. After elimination of sugar tailoring (generating the corresponding aglycons) and diverse hydroxyl moieties, as well as further backbone reorganizations, the final absorbed compounds enter the portal vein circulation towards liver (where other enzymatic transformations take place) and from there to other organs, including behind the digestive tract or via blood towards urine excretion. During this transit along diverse tissues and organs, they are able to carry out strong antiviral, antibacterial, and antiparasitic activities. This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenols structure recognition by specific enzymes produced by intestinal microbial taxa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.