Evidence map›Paper›PMID 25802852›Full record

ArticleBioMed research international2015

Use of adipose-derived mesenchymal stem cells in keratoconjunctivitis sicca in a canine model.

Antonio J Villatoro, Viviana Fernández, Silvia Claros, Gustavo A Rico-Llanos, José Becerra, José A Andrades

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05784519 (Clinical Study of Mesenchymal Stem Cell Eye Drops for Treating Dry Eye Disease), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05784519 early_phase1active not recruitingnot on this mapstarted 2023, after this paper: background citation

Clinical Study of Mesenchymal Stem Cell Eye Drops for Treating Dry Eye Disease

TypeinterventionalSponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolRan2023 to 2028Enrolled10ConditionsMesenchymal Stem Cell, Dry Eye SyndromesArmsMSCs eye drops
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Antonio J VillatoroLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, Biomedical Research Institute of Málaga (IBIMA), University of Málaga, 29071 Málaga, Spain.
Viviana FernándezLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, Biomedical Research Institute of Málaga (IBIMA), University of Málaga, 29071 Málaga, Spain.
Silvia ClarosLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, Biomedical Research Institute of Málaga (IBIMA), University of Málaga, 29071 Málaga, Spain ; Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain.ORCID 0000-0002-3428-8378
Gustavo A Rico-LlanosLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, Biomedical Research Institute of Málaga (IBIMA), University of Málaga, 29071 Málaga, Spain ; Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain ; Centro Andaluz de Nanomedicina y Biotecnología (BIONAND), University of Málaga, 29590 Málaga, Spain.
José BecerraLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, Biomedical Research Institute of Málaga (IBIMA), University of Málaga, 29071 Málaga, Spain ; Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain ; Centro Andaluz de Nanomedicina y Biotecnología (BIONAND), University of Málaga, 29590 Málaga, Spain.
José A AndradesLaboratory of Bioengineering and Tissue Regeneration (LABRET), Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, Biomedical Research Institute of Málaga (IBIMA), University of Málaga, 29071 Málaga, Spain ; Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain.
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESInstituto de Investigación Biomédica de Málaga · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Keratoconjunctivitis sicca (KCS) or dry eye disease (DED) is an immune-mediated multifactorial disease, with high level of prevalence in humans and dogs. Our aim in this study was to investigate the therapeutic effects of allogeneic adipose-derived mesenchymal stromal cells (Ad-MSCs) implanted around the lacrimal glands in 12 dogs (24 eyes) with KCS, which is refractory to current available treatments. Schirmer tear test (STT) and ocular surface integrity were assessed at 0 (before treatment), 3, 6, and 9 months after treatment. Average STT values and all clinical signs showed a statistically significant change (P < 0.001) during the follow-up with reduction in all ocular parameters scored: ocular discharge, conjunctival hyperaemia, and corneal changes, and there were no signs of regression or worsening. Implanted cells were well tolerated and were effective reducing clinical signs of KCS with a sustained effect during the study period. None of the animals showed systemic or local complications during the study. To our knowledge, this is the first time in literature that implantation of allogeneic Ad-MSCs around lacrimal glands has been found as an effective therapeutic alternative to treat dogs with KCS. These results could reinforce a good effective solution to be extrapolated to future studies in human.

Indexed as

Mesenchymal Stem Cell TransplantationAdipose TissueAnimalsCell DifferentiationCell LineageCell ProliferationCells, CulturedCell SeparationCell ShapeDisease Models, AnimalDogsEyeFemaleFlow CytometryHumansKeratoconjunctivitis Sicca

Identifiers

PMID25802852
PMCPMC4352730
OpenAlexW1987772516

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.