Evidence map›Paper›PMID 25802845›Full record

SynthesisBioMed research international2015

Effectiveness of hyaluronic acid administration in treating adhesive capsulitis of the shoulder: a systematic review of randomized controlled trials.

Lin-Chien Lee, Fu-Kong Lieu, Hung-Lin Lee, Tao-Hsin Tung

Registry-linked trialOpen access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06379997 (Efficacy of Oral Hyaluronic Acid and Collagen Supplementation Compared With Hyaluronic Acid Infiltration Treatment in Rotator Cuff Tendinopathies), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06379997 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy of Oral Hyaluronic Acid and Collagen Supplementation Compared With Hyaluronic Acid Infiltration Treatment in Rotator Cuff Tendinopathies: A Prospective Study

TypeinterventionalSponsorI.R.C.C.S. Fondazione Santa LuciaRan2024 to 2025Enrolled50ConditionsTendinitis of Shoulder, Hyaluronic Acid, Dietary Supplements, Shoulder PainArmsCollagen, Hyaluronic Acid, Vitamin C, and Manganese, Intra-articular infiltration
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Hydrodilatation with corticosteroids is the most effective conservative management for frozen shoulder.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021
    Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Lin-Chien LeeDepartment of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei 11220, Taiwan.ORCID 0000-0002-4391-5134
Fu-Kong LieuDepartment of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei 11220, Taiwan.ORCID 0000-0001-9568-7973
Hung-Lin LeeDepartment of Nursing, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0002-7938-0303
Tao-Hsin TungDepartment of Medical Research and Education, Cheng Hsin General Hospital, Taipei 11220, Taiwan ; Department of Public Health, School of Medicine, Fu Jen Catholic University, Taipei 24205, Taiwan.ORCID 0000-0003-2097-8375
Cheng Hsin General Hospital · TWFu Jen Catholic University · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAdhesive capsulitis (AC) of the shoulder presents with an insidious onset of pain and progressive limitation of shoulder movement.

objectivesTo investigate whether intra-articular hyaluronic acid (HA) administration alone is superior to conventional therapies and whether the addition of intra-articular HA administration to conventional therapies improves clinical outcomes in patients with AC.

methodsThe PubMed, EMBASE, CINAHL, and Cochrane Library electronic databases were searched without language restrictions in July 2014 with a priori defined inclusion and exclusion criteria.

resultsFour randomized controlled trials (273 participants, 278 shoulders) were included in this review. Two trials compared intra-articular HA administration with conventional therapies and 2 trials evaluated intra-articular HA administration as an addition to conventional therapies. Pain and shoulder function/disability outcomes in the HA injection group were not superior to those achieved in the conventional therapy groups. No significant differences in pain or shoulder function/disability outcomes were noted between the groups with and without adjunctive HA administration.

conclusionsIntra-articular HA administration alone is not superior to conventional AC treatments, and the addition of intra-articular HA administration to conventional therapies does not provide significant added benefits. HA administration in AC patients who are receiving conventional therapies should be evaluated to avoid unnecessary medical expenditure.

Indexed as

BursitisHumansHyaluronic AcidInjections, Intra-ArticularRandomized Controlled Trials as TopicShoulder JointShoulder PainHyaluronic Acid

Identifiers

PMID25802845
PMCPMC4329841
OpenAlexW2037788867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.