Evidence map›Paper›PMID 25802825›Full record

ArticleAdvanced biomedical research2015

Which one is more efficient on propofol 2% injection pain? Magnesium sulfate or ondansetron: A randomized clinical trial.

Poupak Rahimzadeh, Seyed Hamid Reza Faiz, Nasim Nikoobakht, Mohammad Reza Ghodrati

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biomedical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04673500 (Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04673500 nacompletednot on this map

Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain

TypeinterventionalSponsorKing Khalid University HospitalRan2013 to 2014Enrolled160ConditionsInjection Site IrritationArmsPropofol lidocaine through large vein, Propofol lidocaine through small vein
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Major Adverse Cardiac Events with Ondansetron: A Systematic Review.Clinical pharmacology and therapeutics · 2026
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Poupak RahimzadehDepartment of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran.
Seyed Hamid Reza FaizDepartment of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran.
Nasim NikoobakhtDepartment of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Reza GhodratiDepartment of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPainful sensation has been reported after propofol injection in most of the patients but no definite mechanism for this painful sensation has been proposed yet. The present randomized clinical trial compares analgesic effect of ondansetron, magnesium sulphate (MS) and placebo on patients after propofol 2% injection. MATERIALS AND

methodsThe present randomized clinical trial with parallel design was performed on 90 patients American Society of Anesthesiologists I-II undergoing general anesthesia within vitrectomy operation with propofol induction. Subjects were randomly allocated into three groups with 30 patients each: (1) MS group (2) ondansetron group and (3) normal saline (NS) group as placebo group. Anesthesia induction and maintenance were the same between groups. Pain intensity of propofol injection in subjects was assessed by a four-point scale (none 0, mild 1, moderate 2 and severe 3) at four time intervals (5, 10, 20 and 25 s) after injection.

resultsMS and ondansetron had significant impacts on pain reduction after propofol 2% injection in comparison with NS as placebo. Comparing two trial groups did not have any significant priority for analgesic impact.

conclusionUsing ondansetron or MS had no priority on each other on declining propofol injection induced pain.

Indexed as

Magnesium sulfateondansetronpainpropofol

Identifiers

PMID25802825
PMCPMC4361955
OpenAlexW1992459980

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.