ArticleNeural plasticity2015
Effects of trace metal profiles characteristic for autism on synapses in cultured neurons.
Article in Neural plasticity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Association between zinc status and autism spectrum disorder in children and adolescents: a systematic review and meta-analysis of case-control studies.Frontiers in nutrition · 2025Pooled it
- Evaluation of Lead exposure's link to autism-like behavior and Shank 3 gene expression in C57BL/6J mice.The Journal of veterinary medical science · 2026Article
- Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors ofiScience · 2023Article
- GluA1-Shank3 interaction decreases in response to chronic neuronal depolarization.Neuroscience letters · 2023Article
- Effects of Selen on the Antidepressant-like Activity of Agents Affecting the Adenosinergic Neurotransmission.Metabolites · 2022Article
- Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study.Autism research : official journal of the International Society for Autism Research · 2021Article
- Review
- Prenatal exposure to metals and autism spectrum disorder: Current status and future directions.Current opinion in toxicology · 2021Article
- Interpretable Machine Learning Reveals Dissimilarities Between Subtypes of Autism Spectrum Disorder.Frontiers in genetics · 2021Article
- Zinc.Advances in food and nutrition research · 2021Review
- An Overview of the Main Genetic, Epigenetic and Environmental Factors Involved in Autism Spectrum Disorder Focusing on Synaptic Activity.International journal of molecular sciences · 2020Review
- Article
- Influence of maternal zinc supplementation on the development of autism-associated behavioural and synaptic deficits in offspring Shank3-knockout mice.Molecular brain · 2020Article
- Biomarkers in Drug Free Subjects with Depression : Correlation with Tryptophan.Psychiatry investigation · 2019Article
- X-ray Fluorescence Nanotomography of Single Bacteria with a Sub-15 nm Beam.Scientific reports · 2018Article
- Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus.Cell reports · 2018Article
- Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.Scientific reports · 2017Article
- Integrated wetlands for food production.Environmental research · 2016Review
- Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells.Neural plasticity · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various recent studies revealed that biometal dyshomeostasis plays a crucial role in the pathogenesis of neurological disorders such as autism spectrum disorders (ASD). Substantial evidence indicates that disrupted neuronal homeostasis of different metal ions such as Fe, Cu, Pb, Hg, Se, and Zn may mediate synaptic dysfunction and impair synapse formation and maturation. Here, we performed in vitro studies investigating the consequences of an imbalance of transition metals on glutamatergic synapses of hippocampal neurons. We analyzed whether an imbalance of any one metal ion alters cell health and synapse numbers. Moreover, we evaluated whether a biometal profile characteristic for ASD patients influences synapse formation, maturation, and composition regarding NMDA receptor subunits and Shank proteins. Our results show that an ASD like biometal profile leads to a reduction of NMDAR (NR/Grin/GluN) subunit 1 and 2a, as well as Shank gene expression along with a reduction of synapse density. Additionally, synaptic protein levels of GluN2a and Shanks are reduced. Although Zn supplementation is able to rescue the aforementioned alterations, Zn deficiency is not solely responsible as causative factor. Thus, we conclude that balancing Zn levels in ASD might be a prime target to normalize synaptic alterations caused by biometal dyshomeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.