ArticleEvidence-based complementary and alternative medicine : eCAM2015
Comparisons of ethanol extracts of chinese propolis (poplar type) and poplar gums based on the antioxidant activities and molecular mechanism.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Propolis in Obesity and Related Metabolic Disorders: Mechanistic and Clinical Insights-A Scoping Review.Nutrients · 2026Article
- Chemical Profiling and Geographic Differentiation of Ugandan Propolis by GC-MS Through Chemometric Modelling.Molecules (Basel, Switzerland) · 2025Article
- The Comparative Study of the Antioxidant and Antibacterial Effects of Propolis Extracts in Veterinary Medicine.Veterinary sciences · 2024Article
- Poplar Bud (Antioxidants (Basel, Switzerland) · 2024Article
- Characterization of Secondary Metabolites of Leaf Buds from Some Species and Hybrids ofInternational journal of molecular sciences · 2024Article
- New insights of propolis nanoformulation and its therapeutic potential in human diseases.ADMET & DMPK · 2024Review
- An Insight on the Biomedical Potential of Portuguese Propolis from Gerês.Foods (Basel, Switzerland) · 2022Article
- Allergic Inflammation: Effect of Propolis and Its Flavonoids.Molecules (Basel, Switzerland) · 2022Review
- Mixing Propolis from Different Apiaries and Harvesting Years: Towards Propolis Standardization?Antibiotics (Basel, Switzerland) · 2022Article
- Effect of propolis supplementation on athletic performance, body composition, inflammation, and oxidative stress following intense exercise: A triple-blind randomized clinical trial.Food science & nutrition · 2021Article
- Ophthalmic In Situ Gels with Balsam Poplar Buds Extract: Formulation, Rheological Characterization, and Quality Evaluation.Pharmaceutics · 2021Article
- Extracts of Poplar Buds (Plants (Basel, Switzerland) · 2021Article
- Plant Sources Responsible for the Chemical Composition and Main Bioactive Properties of Poplar-Type Propolis.Plants (Basel, Switzerland) · 2020Review
- Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models.Molecules (Basel, Switzerland) · 2019Review
- Chemical Compositions of Propolis from China and the United States and their Antimicrobial Activities AgainstMolecules (Basel, Switzerland) · 2019Article
- Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3K/Akt/mTOR-Mediated Nrf2/HO-1 Pathway.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application.Oxidative medicine and cellular longevity · 2018Review
- Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- The Role of Propolis in Oxidative Stress and Lipid Metabolism: A Randomized Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- The Ethanol Extract of LicoriceEvidence-based complementary and alternative medicine : eCAM · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological activities of propolis are varied from plant sources and the prominent antioxidant effects of Chinese propolis (poplar type) have been extensively reported. Oxidative stress is associated with inflammation and induces many diseases. In the study, to evaluate antioxidant capacities and clarify the underlying molecular mechanisms of ethanol extracts of Chinese propolis (EECP) and ethanol extracts of poplar gums (EEPG), we analyzed their compositions by HPLC, evaluating their free radical scavenging activities and reducing power by chemical analysis methods. Moreover, we studied the roles of EECP and EEPG on the elimination of ROS and expressions of antioxidant genes (HO-1, TrxR1, GCLM, and GCLC) in RAW264.7 cells. We further investigated the effects of MAPKs on the antioxidant genes expression by specific inhibitors. The nucleus translocation effects of Nrf2 were also measured by confocal microscopy analysis. The results indicated that EECP had higher TPC and FDC values but regarding TFC values were not significant. EECP also possessed more contents of 11 compounds than EEPG. Both phytochemical analysis and cell experiment reflected that EECP exerted stronger antioxidant activities than EEPG. EECP and EEPG enhanced endogenous antioxidant defenses by eliminating reactive oxygen species directly and activating Erk-Nrf2-HO1, GCLM, and TrxR1 signal pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.