Evidence map›Paper›PMID 25802439›Full record

ArticleThe Veterinary record2015

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK.

L P Holm, I Hawkins, C Robin, R J Newton, R Jepson, G Stanzani, L A McMahon, P Pesavento, T Carr, T Cogan and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Veterinary record, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Diffuse alveolar damage, acute respiratory distress syndrome (ARDS), and non-cardiogenic pulmonary edema. Part 1: ARDS endotypes, including systemic inflammatory response syndrome and sepsis, with dog and cat examples.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2026
    Review
  2. Presumed successful steroid therapy for suspected thrombotic microangiopathy in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2025
    Article
  3. Review
  4. Clinical utility of estimation of glomerular filtration rate in dogs.Journal of veterinary internal medicine · 2020
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

L P HolmAnderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire SO21 2LL, UK.ORCID http://orcid.org/0000-0002-3426-160X
I HawkinsBridge Pathology, Horner Court, 637 Gloucester Road, Horfield, Bristol BS7 0BJ, UK.
C RobinAnimal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK.
R J NewtonAnimal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK.
R JepsonDepartment of Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK.
G StanzaniDepartment of Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK.
L A McMahonAnderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire SO21 2LL, UK.
P PesaventoDepartment of PMI, University of California, Davis, School of Veterinary Medicine, 4206 VM3A, 1 Shields Avenue, Davis, California 95616, USA.
T CarrMartin and Carr, The Old Well, Station Road, Pershore, Worcestershire WR10 2DB, UK.
T CoganSchool of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, UK.
C G CoutoCouto Veterinary Consultants, Hilliard, Ohio 43026, USA.
R CiancioloInternational Veterinary Renal Pathology Service, Department of Veterinary Biosciences, The Ohio State University, 301 Goss Laboratory, 1925 Coffey Rd, Columbus, Ohio, USA.
D J WalkerAnderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire SO21 2LL, UK.
Animal Health Trust · GBRoyal Veterinary College · GBThe Ohio State University · USUniversity of Bristol · GBUniversity of California, Davis · USWillows Veterinary Centre and Referral Service · GB

Funding

Transgenic Mouse and Biobank CoreP01CA095616 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRENNAN, CAMERON · 2003 to 2012
$20.3M
NCI NIH HHS P01 CA095616
6 · The paper itself

Abstract

To describe the signalment, clinicopathological findings and outcome in dogs presenting with acute kidney injury (AKI) and skin lesions between November 2012 and March 2014, in whom cutaneous and renal glomerular vasculopathy (CRGV) was suspected and renal thrombotic microangiopathy (TMA) was histopathologically confirmed. The medical records of dogs with skin lesions and AKI, with histopathologically confirmed renal TMA, were retrospectively reviewed. Thirty dogs from across the UK were identified with clinicopathological findings compatible with CRGV. These findings included the following: skin lesions, predominantly affecting the distal extremities; AKI; and variably, anaemia, thrombocytopaenia and hyperbilirubinaemia. Known causes of AKI were excluded. The major renal histopathological finding was TMA. All thirty dogs died or were euthanised. Shiga toxin was not identified in the kidneys of affected dogs. Escherichia coli genes encoding shiga toxin were not identified in faeces from affected dogs. CRGV has previously been reported in greyhounds in the USA, a greyhound in the UK, without renal involvement, and a Great Dane in Germany. This is the first report of a series of non-greyhound dogs with CRGV and AKI in the UK. CRGV is a disease of unknown aetiology carrying a poor prognosis when azotaemia develops.

Indexed as

Acute Kidney InjuryAnimalsDog DiseasesDogsFemaleKidney GlomerulusMaleSkin UlcerUnited KingdomVascular DiseasesDermatopathologyHistopathologyInternal medicineKidneysRenal diseaseSkin

Identifiers

PMID25802439
PMCPMC4413843
OpenAlexW2147330781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.