ArticleEuropean journal of applied physiology2015
Effect of aging on hemodynamic response to metaboreflex activation.
Article in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04013022 (The Effects of Lifelong Endurance and Strength Training on the Central and Peripheral Cardiovascular Responses), which is not on this map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Lifelong Endurance and Strength Training on the Central and Peripheral Cardiovascular Responses
Who cites it
24 citing papers in PubMed.
- Short-term water deprivation attenuates the exercise pressor reflex in older female adults.Physiological reports · 2020Trial
- Ischemic preconditioning reduces hemodynamic response during metaboreflex activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Ageing exacerbates the adverse effects of respiratory muscle fatigue on vascular function, locomotor muscle fatigue and exercise performance in males.Experimental physiology · 2026Article
- Does hypertension exacerbate the age-related exaggerated pressor response to dynamic exercise during post-exercise muscle ischemia?Physiological reports · 2025Article
- Cardiac output-mediated regulation of cerebral blood flow during exercise: Clinical perspectives on the indirect impact of muscle metaboreflex.Experimental physiology · 2025Review
- The role of peripheral venous distension reflex in regulating hemodynamics: mini review.Autonomic neuroscience : basic & clinical · 2024Review
- Cardiovascular responses to static handgrip exercise and postexercise ischemia in heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Age-related alterations in the cardiovascular responses to acute exercise in males and females: role of the exercise pressor reflex.Frontiers in physiology · 2023Review
- The exercise pressor reflex: An update.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Acute Exercise with Moderate Hypoxia Reduces Arterial Oxygen Saturation and Cerebral Oxygenation without Affecting Hemodynamics in Physically Active Males.International journal of environmental research and public health · 2022Article
- Influence of locomotor muscle group III/IV afferents on cardiovascular and ventilatory responses in human heart failure during submaximal exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Systolic and diastolic function during cycling at the respiratory threshold between elderly and young healthy individuals.Scientific reports · 2022Article
- Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans.Physiological reports · 2021Article
- Muscle metaboreflex adaptations to exercise training in health and disease.European journal of applied physiology · 2021Review
- A brief bout of exercise in hypoxia reduces ventricular filling rate and stroke volume response during muscle metaboreflex activation.European journal of applied physiology · 2020Article
- Muscle metaboreflex-induced increases in effective arterial elastance: effect of heart failure.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Effect of Combined Mental Task and Metaboreflex Activation on Hemodynamics and Cerebral Oxygenation in Patients With Metabolic Syndrome.Frontiers in physiology · 2020Article
- Effects of exercise in normobaric hypoxia on hemodynamics during muscle metaboreflex activation in normoxia.European journal of applied physiology · 2019Article
- Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity.Current cardiology reviews · 2018Review
- Hemodynamic Responses during Enduro-Motorcycling Performance.Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the present investigation was to assess the role of aging on the contribution of diastolic function during metaboreflex activation. In particular, it aimed to determine whether age-related impairment in diastolic function would produce a different hemodynamic response in elderly subjects (EG) as compared to young controls (CTL).
methodsHemodynamic response to metaboreflex activation obtained by post-exercise muscle ischemia (PEMI) was gathered in 22 EG and 20 healthy CTL. Subjects also performed a control exercise recovery (CER) test to compare data from the PEMI test.
resultsThe main results showed that the EG group reached higher mean arterial blood pressure (MAP) increment than the CTL group during the PEMI test (+11.2 ± 8.6 vs 6.1 ± 6.4 mmHg in the EG and CTL group, respectively). Moreover, the mechanism by which this response was achieved was different between the two groups. In detail, EG reached the target MAP by increasing systemic vascular resistance (+235.2 ± 315.1 vs -44.4 ± 167.7 dynes s(-1) cm(-5) for the EG and the CTL group, respectively), whereas MAP response in the CTL was the result of an increase in cardiac pre-load (-1.5 ± 11.2 vs 14 ± 13.7 ml in end-diastolic volume for the EG and the CTL group, respectively), which led to a rise in stroke volume and cardiac output. Moreover, early filling peak velocities showed a higher response in the CTL than EG group.
conclusionsThis study demonstrates that diastolic function is important for normal hemodynamic adjustment during the metaboreflex and to avoid excessive vasoconstriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.