Evidence map›Paper›PMID 25802221›Full record

ArticleClinical oral investigations2015

Nasolabial symmetry and esthetics in cleft lip and palate: analysis of 3D facial images.

Dries J Desmedt, Thomas J Maal, Mette A Kuijpers, Ewald M Bronkhorst, Anne Marie Kuijpers-Jagtman, Piotr S Fudalej

Abstract read
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Article in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. A Summary of the Existing Data on Cleft Surgical Outcomes: What Do We Not Know?Plastic and reconstructive surgery. Global open · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Craniofacial characteristics and cosmetic satisfaction of patients with sagittal and metopic synostosis: a case-control study using 3D photogrammetric imaging.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
    Article
  7. Article
  8. The Validation of an Innovative Method for 3D Capture and Analysis of the Nasolabial Region in Cleft Cases.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dries J DesmedtDepartment of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen, The Netherlands.
Thomas J MaalDepartment of Maxillofacial Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Mette A KuijpersDepartment of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen, The Netherlands.
Ewald M BronkhorstDepartment of Preventive and Curative Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands.
Anne Marie Kuijpers-JagtmanDepartment of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Nijmegen, The Netherlands.
Piotr S FudalejDepartment of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland. piotr.fudalej@zmk.unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the relationship between nasolabial symmetry and esthetics in subjects with orofacial clefts. MATERIAL AND

methodsEighty-four subjects (mean age 10 years, standard deviation 1.5) with various types of nonsyndromic clefts were included: 11 had unilateral cleft lip (UCL); 30 had unilateral cleft lip and alveolus (UCLA); and 43 had unilateral cleft lip, alveolus, and palate (UCLAP). A 3D stereophotogrammetric image of the face was taken for each subject. Symmetry and esthetics were evaluated on cropped 3D facial images. The degree of asymmetry of the nasolabial area was calculated based on all 3D data points using a surface registration algorithm. Esthetic ratings of various elements of nasal morphology were performed by eight lay raters on a 100 mm visual analog scale. Statistical analysis included ANOVA tests and regression models.

resultsNasolabial asymmetry increased with growing severity of the cleft (p = 0.029). Overall, nasolabial appearance was affected by nasolabial asymmetry; subjects with more nasolabial asymmetry were judged as having a less esthetically pleasing nasolabial area (p < 0.001). However, the relationship between nasolabial symmetry and esthetics was relatively weak in subjects with UCLAP, in whom only vermilion border esthetics was associated with asymmetry.

conclusionsNasolabial symmetry assessed with 3D facial imaging can be used as an objective measure of treatment outcome in subjects with less severe cleft deformity. In subjects with more severe cleft types, other factors may play a decisive role. CLINICAL SIGNIFICANCE: Assessment of nasolabial symmetry is a useful measure of treatment success in less severe cleft types.

Indexed as

Imaging, Three-DimensionalChildCleft LipCleft PalateFemaleHumansMaleCleft lipCleft palateEstheticsFaceImagingMorphologyThree dimensional

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.