ArticleCognitive, affective & behavioral neuroscience2015
Brain morphology of childhood aggressive behavior: A multi-informant study in school-age children.
Article in Cognitive, affective & behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Neural networks of aggression: ALE meta-analyses on trait and elicited aggression.Brain structure & function · 2019Pooled it
- Association of prenatal depression and anxiety with cortical development and behavioral outcomes in 8-year-old children.Journal of affective disorders · 2026Article
- Risk of drug-related aggression in pediatric populations: a pharmacovigilance analysis using the FAERS database.Frontiers in pediatrics · 2026Article
- EEG analysis in patients with schizophrenia based on microstate semantic modeling method.Frontiers in human neuroscience · 2024Article
- Behavioral and neurostructural correlates of childhood physical violence victimization: Interaction with family functioning.Developmental psychobiology · 2023Article
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- Reciprocal Relations Between Conflicted Student-teacher Relationship and Children's Behavior Problems: Within-person Analyses from Norway and the USA.Research on child and adolescent psychopathology · 2023Article
- Abnormalities in electroencephalographic microstates among violent patients with schizophrenia.Frontiers in psychiatry · 2023Article
- Superstorm Sandy exposureFrontiers in neuroscience · 2023Article
- Individual differences in brain structure and self-reported empathy in children.Cognitive, affective & behavioral neuroscience · 2022Article
- Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI.International journal of environmental research and public health · 2021Article
- Structural Brain Development and Aggression: A Longitudinal Study in Late Childhood.Cognitive, affective & behavioral neuroscience · 2021Article
- Cortical Correlates of Impulsive Aggressive Behavior in Pediatric Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Neuroimaging contrast across the cortical hierarchy is the feature maximally linked to behavior and demographics.NeuroImage · 2020Article
- Sex-specific contribution of DHEA-cortisol ratio to prefrontal-hippocampal structural development, cognitive abilities and personality traits.Journal of neuroendocrinology · 2019Article
- Emerging roles of Fgf14 in behavioral control.Behavioural brain research · 2019Article
- Larger Amygdala Volume Mediates the Association Between Prenatal Maternal Stress and Higher Levels of Externalizing Behaviors: Sex Specific Effects in Project Ice Storm.Frontiers in human neuroscience · 2019Article
- Development of the cerebral cortex and the effect of the intrauterine environment.The Journal of physiology · 2018Review
- Alexithymia and reactive aggression: The role of the amygdala.Psychiatry research. Neuroimaging · 2018Article
- Pleiotropic Contribution ofFrontiers in behavioral neuroscience · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFew studies have focused on the neuroanatomy of aggressive behavior in children younger than 10 years. Here, we explored the neuroanatomical correlates of aggression in a population-based sample of 6- to 9-year-old children using a multiple-informant approach.
methodsMagnetic resonance (MR) scans were acquired from 566 children from the Generation R study who participated in the Berkeley Puppet Interview and whose parents had completed the Child Behavior Checklist. Linear regression analyses were used to examine associations between aggression and amygdala and hippocampal volume. We performed surface-based analyses to study the association between aggression and cortical thickness, surface area, and gyrification.
resultsAggressive behavior was associated with smaller amygdala (p < .05) but not hippocampal volume. Aggression was associated with a thinner cortex in the left precentral cortex (p < .01) and in a cluster including the right inferior parietal, supramarginal, and postcentral cortex (p < .001). Gender moderated the association between aggression and cortical thickness in the right medial posterior cortex (p = .001) and the right prefrontal cortex (p < .001). Aggression was associated with decreased gyrification in a large cluster including the right precentral, postcentral, frontal, and parietal cortex (p = .01). Moreover, aggression was associated with decreased gyrification in the right occipital and parietal cortex (p = .02).
conclusionWe found novel evidence that childhood aggressive behavior is related to decreased amygdala volume, decreased sensorimotor cortical thickness, and decreased global right hemisphere gyrification. Aggression is related to cortical thickness in regions associated with the default mode network, with negative associations in boys and positive associations in girls.
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