Evidence map›Paper›PMID 25801706›Full record

ArticleNeuron2015

Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.

Adrian Israelson, Dara Ditsworth, Shuying Sun, SungWon Song, Jason Liang, Marian Hruska-Plochan, Melissa McAlonis-Downes, Salah Abu-Hamad, Guy Zoltsman, Tom Shani and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 115 citations in OpenAlex.

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  13. MIF contribution to progressive brain diseases.Journal of neuroinflammation · 2024
    Review
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Adrian IsraelsonDepartment of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel. Electronic address: adriani@bgu.ac.il.
Dara DitsworthLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Shuying SunLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0670, USA.
SungWon SongThe Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA; Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43205, USA.
Jason LiangLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Marian Hruska-PlochanDepartment of Anesthesiology, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Melissa McAlonis-DownesLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Salah Abu-HamadDepartment of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel.
Guy ZoltsmanDepartment of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel.
Tom ShaniDepartment of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel.
Marcus MaldonadoLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Anh BuiLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Michael NavarroDepartment of Anesthesiology, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Huilin ZhouLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Martin MarsalaDepartment of Anesthesiology, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Brian K KasparThe Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA; Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43205, USA; Department of Neuroscience, The Ohio State University, Columbus, OH 43205, USA.
Sandrine Da CruzLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA.
Don W ClevelandLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0670, USA; Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093-0670, USA. Electronic address: dcleveland@ucsd.edu.
Ludwig Cancer Research · USUniversity of California, San Diego · USBen-Gurion University of the Negev · ILNationwide Children's Hospital · USThe Ohio State University · US

Funding

NEURONAL FILAMENT SYNTHESIS, ASSEMBLY, AND FUNCTIONR01NS027036 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bogdan Bintu, Don W Cleveland · 1989 to 2026
$11.8M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Role of Potent Trophic Factors on Glia and Motor Neurons in ALSR01NS064492 · NINDS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI KASPAR, BRIAN K. · 2009 to 2013
$1.5M
NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS027036NINDS NIH HHS R01 NS064492NINDS NIH HHS R01 NS27036NINDS NIH HHS R01 NS644912
6 · The paper itself

Abstract

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by loss of motor neurons and accompanied by accumulation of misfolded SOD1 onto the cytoplasmic faces of intracellular organelles, including mitochondria and the endoplasmic reticulum (ER). Using inhibition of misfolded SOD1 deposition onto mitochondria as an assay, a chaperone activity abundant in nonneuronal tissues is now purified and identified to be the multifunctional macrophage migration inhibitory factor (MIF), whose activities include an ATP-independent protein folding chaperone. Purified MIF is shown to directly inhibit mutant SOD1 misfolding. Elevating MIF in neuronal cells suppresses accumulation of misfolded SOD1 and its association with mitochondria and the ER and extends survival of mutant SOD1-expressing motor neurons. Accumulated MIF protein is identified to be low in motor neurons, implicating correspondingly low chaperone activity as a component of vulnerability to mutant SOD1 misfolding and supporting therapies to enhance intracellular MIF chaperone activity.

Indexed as

Protein FoldingAcid PhosphataseAnimalsCell DifferentiationCells, CulturedCholine O-AcetyltransferaseEndoplasmic ReticulumGreen Fluorescent ProteinsHumansInduced Pluripotent Stem CellsIsoenzymesLiverMacrophage Migration-Inhibitory FactorsMiceMice, TransgenicMitochondriaAcid PhosphataseCholine O-Acetyltransferaseenhanced green fluorescent proteinGreen Fluorescent ProteinsIsoenzymesMacrophage Migration-Inhibitory FactorsNerve Tissue ProteinsRibosomal ProteinsRpl10a protein, ratSOD1 protein, humanSod1 protein, mouseSod1 protein, ratSuperoxide DismutaseSuperoxide Dismutase-1Tartrate-Resistant Acid Phosphatase

Identifiers

PMID25801706
PMCPMC4393372
OpenAlexW2044659434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.