Evidence map›Paper›PMID 25801692›Full record

ArticleInternational journal of obesity (2005)2015

Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A community-based study.

L Kheirandish-Gozal, A Gileles-Hillel, M L Alonso-Álvarez, E Peris, R Bhattacharjee, J Terán-Santos, J Duran-Cantolla, D Gozal

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Nasal biomarker inflammatory profile in response to intranasal corticosteroids in pediatric obstructive sleep apnea syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Trial
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. [The relationship between adenoid and tonsil hypertrophy and asthma in children and analysis of changes in asthma after adenotonsillectomy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Review
  12. Article
  13. Coagulation and Fibrinolysis in Obstructive Sleep Apnoea.International journal of molecular sciences · 2021
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Risk Factors for Obstructive Sleep Apnea Syndrome in Children: State of the Art.International journal of environmental research and public health · 2019
    Review
  20. Elevated Serum Markers of Acute Kidney Injury in Patients With Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

L Kheirandish-GozalSection of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.
A Gileles-HillelSection of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.
M L Alonso-Álvarez1] Sleep Unit, Burgos, Spain [2] CIBER of Respiratory Diseases. Instituto Carlos III.CIBERES, Burgos, Spain [3] Hospital Universitario de Burgos (HUBU), Burgos, Spain.
E PerisSection of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.
R BhattacharjeeSection of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.
J Terán-Santos1] Sleep Unit, Burgos, Spain [2] CIBER of Respiratory Diseases. Instituto Carlos III.CIBERES, Burgos, Spain [3] Hospital Universitario de Burgos (HUBU), Burgos, Spain.
J Duran-Cantolla1] Sleep Unit, Burgos, Spain [2] CIBER of Respiratory Diseases. Instituto Carlos III.CIBERES, Burgos, Spain [3] Hospital Universitario de Araba, Vitoria, Spain.
D GozalSection of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.
University of Chicago · US

Funding

NEUROCOGNITIVE FUNCTION IN SNORING CHILDRENR01HL065270 · NHLBI · UNIVERSITY OF LOUISVILLE · PI GOZAL, DAVID · 1999 to 2014
$5.0M
NHLBI NIH HHS HL-65270NHLBI NIH HHS R01 HL065270
6 · The paper itself

Abstract

backgroundObesity and obstructive sleep apnea syndrome (OSA) are highly prevalent and frequently overlapping conditions in children that lead to systemic inflammation, the latter being implicated in the various end-organ morbidities associated with these conditions.

aimTo examine the effects of adenotonsillectomy (T&A) on plasma levels of inflammatory markers in obese children with polysomnographically diagnosed OSA who were prospectively recruited from the community.

methodsObese children prospectively diagnosed with OSA, underwent T&A and a second overnight polysomnogram (PSG) after surgery. Plasma fasting morning samples obtained after each of the two PSGs were assayed for multiple inflammatory and metabolic markers including interleukin (IL)-6, IL-18, plasminogen activator inhibitor-1 (PAI-1), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9), adiponectin, apelin C, leptin and osteocrin.

resultsOut of 122 potential candidates, 100 obese children with OSA completed the study with only one-third exhibiting normalization of their PSG after T&A (that is, apnea-hypopnea index (AHI) ≤1/hour total sleep time). However, overall significant decreases in MCP-1, PAI-1, MMP-9, IL-18 and IL-6, and increases in adropin and osteocrin plasma concentrations occurred after T&A. Several of the T&A-responsive biomarkers exhibited excellent sensitivity and moderate specificity to predict residual OSA (that is, AHI⩾5/hTST).

conclusionsA defined subset of systemic inflammatory and metabolic biomarkers is reversibly altered in the context of OSA among community-based obese children, further reinforcing the concept on the interactive pro-inflammatory effects of sleep disorders such as OSA and obesity contributing to downstream end-organ morbidities.

Indexed as

AdenoidectomyTonsillectomyAdiponectinAdolescentBiomarkersChemokine CCL2ChildChild, PreschoolFemaleHumansInflammationInterleukin-18Interleukin-6LeptinMaleMatrix Metalloproteinase 9AdiponectinBiomarkersCCL2 protein, humanChemokine CCL2IL6 protein, humanInterleukin-18Interleukin-6LeptinMatrix Metalloproteinase 9Muscle ProteinsOSTN protein, humanPlasminogen Activator Inhibitor 1SERPINE1 protein, humanTranscription Factors

Identifiers

PMID25801692
PMCPMC4496251
OpenAlexW2077569934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.