ArticleJournal of the American Society for Mass Spectrometry2015
Separation of opiate isomers using electrospray ionization and paper spray coupled to high-field asymmetric waveform ion mobility spectrometry.
Article in Journal of the American Society for Mass Spectrometry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Rapid and Accurate Identification of Microorganisms Using Ion Mobility-Mass Spectrometry.International journal of mass spectrometry · 2025Article
- Plasma drug screening using paper spray mass spectrometry with integrated solid phase extraction.Drug testing and analysis · 2025Article
- A High-Throughput Ion Mobility Spectrometry-Mass Spectrometry Screening Method for Opioid Profiling.Journal of the American Society for Mass Spectrometry · 2022Article
- Article
- Separating chiral isomers of amphetamine and methamphetamine using chemical derivatization and differential mobility spectrometry.Analytical science advances · 2020Article
- Effects of Solvent Vapor Modifiers for the Separation of Opioid Isomers in Micromachined FAIMS-MS.Journal of the American Society for Mass Spectrometry · 2019Article
- Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM).International journal of mass spectrometry · 2018Article
- Aptamer-modified carbon nanomaterial based sorption coupled to paper spray ion mobility spectrometry for highly sensitive and selective determination of methamphetamine.Mikrochimica acta · 2018Article
- Ambient Ionization and FAIMS Mass Spectrometry for Enhanced Imaging of Multiply Charged Molecular Ions in Biological Tissues.Analytical chemistry · 2016Article
- Development of a prototype blood fractionation cartridge for plasma analysis by paper spray mass spectrometry.Clinical mass spectrometry (Del Mar, Calif.) · 2016Article
- Rapid screening and identification of novel psychoactive substances using PaperSpray interfaced to high resolution mass spectrometry.Clinical mass spectrometry (Del Mar, Calif.) · 2016Article
- Quantitative mass spectrometry methods for pharmaceutical analysis.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Review
- Achieving High Resolution Ion Mobility Separations Using Traveling Waves in Compact Multiturn Structures for Lossless Ion Manipulations.Analytical chemistry · 2016Article
- Ionization Suppression and Recovery in Direct Biofluid Analysis Using Paper Spray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Portable, Battery Operated Capillary Electrophoresis with Optical Isomer Resolution Integrated with Ionization Source for Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements.Clinical chemistry · 2016Review
- Characterization of Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations.Analytical chemistry · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One limitation in the growing field of ambient or direct analysis methods is reduced selectivity caused by the elimination of chromatographic separations prior to mass spectrometric analysis. We explored the use of high-field asymmetric waveform ion mobility spectrometry (FAIMS), an ambient pressure ion mobility technique, to separate the closely related opiate isomers of morphine, hydromorphone, and norcodeine. These isomers cannot be distinguished by tandem mass spectrometry. Separation prior to MS analysis is, therefore, required to distinguish these compounds, which are important in clinical chemistry and toxicology. FAIMS was coupled to a triple quadrupole mass spectrometer, and ionization was performed using either a pneumatically assisted heated electrospray ionization source (H-ESI) or paper spray, a direct analysis method that has been applied to the direct analysis of dried blood spots and other complex samples. We found that FAIMS was capable of separating the three opiate structural isomers using both H-ESI and paper spray as the ionization source.
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Registered trials
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