ArticleImmunology and cell biology2015
Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics.
Article in Immunology and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- The ageing immune system and its battle with viruses.The Journal of general virology · 2026Review
- The challenge and promise of studying human antigen-specific T cells.Nature reviews. Immunology · 2026Review
- Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.Immunological reviews · 2026Review
- The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.Immunological reviews · 2026Review
- Modeling TCR-Epitope Recognition Specificity: What We Should Learn to Succeed.Immunological reviews · 2026Review
- Immunogenicity of Non-Mutated Ovarian Cancer-Specific Antigens.Current oncology (Toronto, Ont.) · 2024Article
- Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan.Nature immunology · 2023Article
- Article
- Broad-Based Influenza-Specific CD8Viruses · 2021Article
- Genetic Bias, Diversity Indices, Physiochemical Properties and CDR3 Motifs Divide Auto-Reactive from Allo-Reactive T-Cell Repertoires.International journal of molecular sciences · 2021Article
- An overview of immunoinformatics approaches and databases linking T cell receptor repertoires to their antigen specificity.Immunogenetics · 2020Review
- Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life.Frontiers in immunology · 2020Article
- A Framework for Annotation of Antigen Specificities in High-Throughput T-Cell Repertoire Sequencing Studies.Frontiers in immunology · 2019Article
- The expanding role of systems immunology in decoding the T cell receptor repertoire.Current opinion in systems biology · 2018Article
- Exploring the pre-immune landscape of antigen-specific T cells.Genome medicine · 2018Article
- Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness.PLoS biology · 2018Article
- Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.The Journal of clinical investigation · 2018Article
- T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.European journal of immunology · 2018Article
- Single-Cell Approach to Influenza-Specific CD8Frontiers in immunology · 2018Article
- Article
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23 authors.
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Abstract
Basic parameters of the naive antigen (Ag)-specific T-cell repertoire in humans remain poorly defined. Systematic characterization of this 'ground state' immunity in comparison with memory will allow a better understanding of clonal selection during immune challenge. Here, we used high-definition cell isolation from umbilical cord blood samples to establish the baseline frequency, phenotype and T-cell antigen receptor (TCR) repertoire of CD8(+) T-cell precursor populations specific for a range of viral and self-derived Ags. Across the board, these precursor populations were phenotypically naive and occurred with hierarchical frequencies clustered by Ag specificity. The corresponding patterns of TCR architecture were highly ordered and displayed partial overlap with adult memory, indicating biased structuring of the T-cell repertoire during Ag-driven selection. Collectively, these results provide new insights into the complex nature and dynamics of the naive T-cell compartment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.