Evidence map›Paper›PMID 25801281›Full record

SynthesisSleep & breathing = Schlaf & Atmung2015

Periodontitis and obstructive sleep apnea's bidirectional relationship: a systematic review and meta-analysis.

Thikriat S Al-Jewair, Reham Al-Jasser, Khalid Almas

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03459638 (Periodontitis as a Potential Early Risk Indicator for Diabetes Mellitus, Atherosclerotic Cardiovascular Disease, Metabolic Syndrome and Obstructive Sleep Apnea Syndrome), which is not on this map. Cited by 41 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03459638 completednot on this mapstarted 2018, after this paper: background citation

Periodontitis as a Potential Early Risk Indicator for Diabetes Mellitus, Atherosclerotic Cardiovascular Disease, Metabolic Syndrome and Obstructive Sleep Apnea Syndrome

Typeobservational_patient_registrySponsorAcademic Centre for Dentistry in AmsterdamRan2018 to 2020Enrolled105ConditionsDiabetes Mellitus, Periodontal Diseases, Cardiovascular Diseases, Obstructive Sleep Apnea SyndromeArmsScreening for DM, ASCVD, MetS and OSAS
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  17. Sleep and periodontal health.Periodontology 2000 · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thikriat S Al-JewairDivision of Dental Public Health, Department of Preventive Dental Sciences, College of Dentistry, University of Dammam, Dammam, Saudi Arabia. taljewair@gmail.com.
Reham Al-JasserDepartment of Periodontics, State University of New York at Buffalo, Buffalo, NY, USA. r.aljasser@gmail.com.
Khalid AlmasDivision of Periodontology, Department of Preventive Dental Sciences, College of Dentistry, University of Dammam, Dammam, Saudi Arabia. kalmas@uod.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study is to evaluate the association between periodontal disease and obstructive sleep apnea (OSA).

methodsElectronic search using PubMed, Cumulative Index to Nursing and Allied Health (CINAHL), Cochrane Central Trial Registry, Cochrane Database of Systematic Reviews, Scopus, and Embase was carried out for randomized controlled trials, longitudinal, cohort, case-control, and epidemiological studies on humans, published until October 2014. Manual searches were also performed. The participants considered were adult subjects with OSA and chronic periodontitis. The authors reviewed all articles and extracted data using a customized data abstraction sheet. Methodological quality assessment was carried out using the Newcastle-Ottawa Quality Assessment Scale.

resultsSix studies met the inclusion criteria set for this review. They evaluated the association between periodontal disease and OSA and the efficacy of periodontal interventions on OSA occurrence and severity. The periodontal disease outcome measures included clinical attachment loss, periodontal pocket depth, oral hygiene indices, radiographic alveolar bone loss, and salivary cytokines. Meta-analysis of four studies revealed a statistically significant association between periodontal disease and OSA (pooled odds ratio = 1.65, 95 % confidence interval (CI) = 1.11, 2.46, P = 0.01). There is insufficient evidence on the efficacy of periodontal disease interventions.

conclusionsThere is some evidence to a plausible association between periodontal disease and OSA. Evidence on the efficacy of periodontal disease interventions is insufficient. The causal-effect relationship of periodontal disease and OSA is debatable. Further research with case-control studies is warranted.

Indexed as

HumansOdds RatioPeriodontitisRandomized Controlled Trials as TopicSleep Apnea, ObstructiveStatistics as TopicTreatment OutcomeOral and systemic healthOSAPeriodontal diseasePeriodontal intervention

Identifiers

PMID25801281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.