Evidence map›Paper›PMID 25801113›Full record

ArticleSurgical endoscopy2016

The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy.

Özgür Balasar, Tuğrul Çakır, Özgür Erkal, Arif Aslaner, Bülent Çekiç, Mehmet Uyar, Nurullah Bülbüller, Mehmet Tahir Oruç

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Towards precision medicine in bariatric surgery prescription.Reviews in endocrine & metabolic disorders · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Özgür BalasarDepartment of Medical Genetics, Dr. Faruk Sükan Maternity and Pediatric Hospital, Konya, Turkey.
Tuğrul ÇakırGeneral Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey. tugrul-cakir@hotmail.com.
Özgür ErkalDepartment of Medical Genetics, Antalya Training and Research Hospital, Muratpaşa, Antalya, Turkey.
Arif AslanerGeneral Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey.
Bülent ÇekiçRadiology Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, Turkey.
Mehmet UyarDepartment of Public Health, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Nurullah BülbüllerGeneral Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey.
Mehmet Tahir OruçGeneral Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey.
Antalya Eğitim ve Araştırma Hastanesi · TRNecmettin Erbakan University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRemarkable differences in weight loss have been observed in obese patients undergoing laparoscopic sleeve gastrectomy (LSG). These high variations might be partly explained by genetic factors. The rs9939609 fat mass and obesity-associated gene (FTO) polymorphism has been implicated in the susceptibility of obesity. We aimed to explore the effects of the rs9939609 FTO gene polymorphism on weight loss among severely obese patients applying for LSG. MATERIALS AND

methodsAll individuals were analyzed for the FTO rs9939609 gene polymorphism. A total of 74 morbid obese patients (20 male, 54 female) were operated. Body weight and body mass index (BMI) were measured at before LSG and after surgery at the sixth month.

resultsTwenty-eight patients (37.8%) had genotype TT (wild-type allel), 36 patients (48.6%) had genotype TA, and 10 patients (13.5%) had genotype AA. In both wild-type group and mutant group, BMI and weight levels decreased at the sixth month after surgery. Percent of excess weight loss (EWL) at 6 months of follow-up was similar in both groups. There were no differences between the mutant and wild-type groups percent of EWL at the sixth month after applying LSG.

conclusionOur data showed that the rs9939609 FTO gene polymorphism is not a useful genetic test prior to LSG to help clinicians predicting the weight loss for severely obese patients in short-term follow-up.

Indexed as

GastrectomyPolymorphism, Single NucleotideAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOFemaleGenotypeHumansLaparoscopyMaleMiddle AgedObesity, MorbidProteinsWeight LossYoung AdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanProteinsLaparoscopic sleeve gastrectomyrs9939609 FTO gene polymorphismWeight loss

Identifiers

PMID25801113
OpenAlexW1966312699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.