Evidence map›Paper›PMID 25801106›Full record

SynthesisSurgical endoscopy2015

Systematic review and meta-analysis for laparoscopic versus open colon surgery with or without an ERAS programme.

W R Spanjersberg, J D P van Sambeeck, A Bremers, C Rosman, C J H M van Laarhoven

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04201730 (A Single Center, Open, Randomized Clinical Trial：Study on the Efficacy and Safety of Enhanced Recovery After Surgery （ERAS）in Gastrointestinal Cancer), which is not on this map. Cited by 84 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 8 pooled it
22.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04201730 nacompletednot on this mapstarted 2019, after this paper: background citation

A Single Center, Open, Randomized Clinical Trial：Study on the Efficacy and Safety of Enhanced Recovery After Surgery （ERAS）in Gastrointestinal Cancer

TypeinterventionalSponsorHuashan HospitalRan2019 to 2021Enrolled356ConditionsEnhanced Recovery After Surgery, Gastrointestinal CancerArmsEnhanced Recovery After Surgery （ERAS）
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 8 syntheses or guidelines pooled it, 197 citations in OpenAlex.

  1. Pooled it
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  3. [Enhanced recovery after surgery-Does the ERAS concept keep its promises].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
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  15. Sham Feeding with Chewing Gum in Early Stage of Acute Pancreatitis: A Randomized Clinical Trial.Medical science monitor : international medical journal of experimental and clinical research · 2017
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  18. Risk factors for not achieving stoma self-care proficiency at hospital discharge and development of a clinical prediction model: A study based on the Danish Stoma Database.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

W R SpanjersbergDepartment of Surgery, Radboud University Medical Centre, Huispost 690, Postbus 9101, 6500 HB, Nijmegen, The Netherlands. richard.spanjersberg@radboudumc.nl.
J D P van SambeeckDepartment of Surgery, Radboud University Medical Centre, Huispost 690, Postbus 9101, 6500 HB, Nijmegen, The Netherlands.
A BremersDepartment of Surgery, Radboud University Medical Centre, Huispost 690, Postbus 9101, 6500 HB, Nijmegen, The Netherlands.
C RosmanDepartment of Surgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
C J H M van LaarhovenDepartment of Surgery, Radboud University Medical Centre, Huispost 690, Postbus 9101, 6500 HB, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLCanisius-Wilhelmina Ziekenhuis · NLRadboud University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent years, conventional colorectal resection and its aftercare have increasingly become replaced by laparoscopic surgery and enhanced recovery after surgery (ERAS) pathways, respectively.

objectiveTo ascertain whether combining laparoscopy and ERAS have additional value within colorectal surgery.

methodsA systematic review with meta-analysis was performed with two primary research questions; does laparoscopy offer an advantage when all patients receive ERAS perioperative care and does ERAS offer advantages in a laparoscopically operated patient population. All randomised and controlled clinical trials were identified using MEDLINE, EMBASE and Cochrane databases.

resultsPrimary search resulted in 319 hits. After inclusion criteria were applied, three RCTs and six CCTs were included in the meta-analysis. For laparoscopically operated patients with/without ERAS, no differences in morbidity were found and postoperative hospital stay favoured ERAS (MD -2.34 [-3.77, -0.91], Z = 3.20, p = 0.001). When comparing laparoscopy and open surgery within ERAS, major morbidity was significantly reduced in the laparoscopic group (OR 0.42 [0.26, 0.66], Z = 3.73, p = 0.006). Other outcome parameters showed no differences. Quality of included studies was considered moderate to poor overall with small sample sizes.

conclusionWhen laparoscopy and ERAS are combined, major morbidity and hospital stay are reduced. The reduction in morbidity seems to be due to laparoscopy rather than ERAS, so laparoscopy by itself offers independent advantages beyond ERAS care. Quality of included studies was moderate to poor, so conclusions should be regarded with some reservations.

Indexed as

Clinical Trials as TopicColonic DiseasesColorectal SurgeryDigestive System Surgical ProceduresHumansLaparoscopyLength of StayPatient ReadmissionPerioperative CareColon surgeryERASLaparoscopic surgeryMeta-analysisSystematic review

Identifiers

PMID25801106
PMCPMC4648973
OpenAlexW2060549990

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.