Evidence map›Paper›PMID 25800697›Full record

ArticleNature communications2015

Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity.

Stefan Harmsen, Matthew A Bedics, Matthew A Wall, Ruimin Huang, Michael R Detty, Moritz F Kircher

Abstract read
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Review
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  11. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
  12. Article
  13. Review
  14. Multiplexed imaging in oncology.Nature biomedical engineering · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. In memory of Michael R. Detty, PhD.Nanotheranostics · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefan Harmsen *Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.
Matthew A Bedics *Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, United States.
Matthew A WallDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.
Ruimin HuangDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.
Michael R DettyDepartment of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, United States.
Moritz F KircherDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MRI-Photoacoustic-Raman Nanostars for Pre- and Intraoperative Multimodal ImagingR01EB017748 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI KIRCHER, MORITZ FLORIAN · 2014 to 2017
$1.6M
Structural biology and high resolution studies of P-glycoproteinR01GM094367 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, GEOFFREY A · 2010 to 2013
$1.3M
Combined Pre & Intraoperative Brain Tumor Imaging Strategy using a Dual-ModalityK08CA163961 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KIRCHER, MORITZ FLORIAN · 2012 to 2016
$845k
NCI NIH HHS K08 CA163961NCI NIH HHS P30 CA008748NIBIB NIH HHS R01 EB017748NIGMS NIH HHS GM-94367NIGMS NIH HHS R01 GM094367
6 · The paper itself

Abstract

High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection.

Indexed as

Metal NanoparticlesAdsorptionChalcogensColoring AgentsGoldHeterocyclic Compounds, 3-RingSpectrum Analysis, RamanSurface PropertiesChalcogensColoring AgentsGoldHeterocyclic Compounds, 3-Ring

Identifiers

PMID25800697
PMCPMC4372816

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.