ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2015
Relationship Between Metabolites Composition and Biological Activities of Phyllanthus niruri Extracts Prepared by Different Drying Methods and Solvents Extraction.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Integrated Metabolomics and Machine Learning Reveal Drying-Dependent Phenolic Markers in Asteraceae Edible Plants From Ulleungdo Island.Food science & nutrition · 2026Article
- Mutant-Selective Binding ofInternational journal of molecular sciences · 2026Article
- Metabolomics based biomarker identification of anti-diabetes and anti-obesity properties of Malaysian herbs.Metabolomics : Official journal of the Metabolomic Society · 2022Review
- Scale-up approach for supercritical fluid extraction with ethanol-water modified carbon dioxide on Phyllanthus niruri for safe enriched herbal extracts.Scientific reports · 2021Article
- UHPLC-UV/PDA Method Validation for Simultaneous Quantification of Luteolin and Apigenin Derivatives fromMolecules (Basel, Switzerland) · 2021Article
- NMR-Based Metabolomics Profiling for Radical Scavenging and Anti-Aging Properties of Selected Herbs.Molecules (Basel, Switzerland) · 2019Article
- Phytochemical composition and in vitro antioxidant potential ofJournal of food science and technology · 2018Article
- Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd.Plants (Basel, Switzerland) · 2017Article
- Characterization of Metabolite Profile in Phyllanthus niruri and Correlation with Bioactivity Elucidated by Nuclear Magnetic Resonance Based Metabolomics.Molecules (Basel, Switzerland) · 2017Article
- Rapid investigation of α-glucosidase inhibitory activity of Phaleria macrocarpa extracts using FTIR-ATR based fingerprinting.Journal of food and drug analysis · 2017Article
- Bioguided Fraction and Isolation of the Antitumor Components fromBioMed research international · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study investigated the changes in the metabolite, antioxidant and α-glucosidase inhibitory activities of Phyllanthus niruri after three drying treatments: air, freeze and oven dryings. Water extracts and extracts obtained using different solvent ratios of ethanol and methanol (50, 70, 80 and 100%) were compared. The relationships among the antioxidant, α-glucosidase inhibitory activity and metabolite levels of the extracts were evaluated using partial least-square analysis (PLS). The solvent selectivity was assessed based on the phytochemical constituents present in the extract and their concentrations quantitatively analyzed using high performance liquid chromatography. The freeze-dried P. niruri samples that were extracted with the mixture of ethanol or methanol with low ratio of water showed higher biological activity values compared with the other extracts. The PLS results for the ethanolic with different ratio and water extracts demonstrated that phenolic acids (chlorogenic acid and ellagic acid) and flavonoids were highly linked to strong α-glucosidase inhibitory and antioxidant activities.
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