ArticleJournal of clinical research in pediatric endocrinology2015
Turner syndrome and associated problems in Turkish children: a multicenter study.
Article in Journal of clinical research in pediatric endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Global prevalence of autoimmune diseases in turner syndrome: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- The prevalence of hypertension in paediatric Turner syndrome: a systematic review and meta-analysis.Journal of human hypertension · 2023Pooled it
- Prevalence of Celiac Disease in Patients With Turner Syndrome: Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Prevalence of autoimmune thyroid diseases among the Turner Syndrome patients: meta-analysis of cross sectional studies.BMC research notes · 2018Pooled it
- Mucocutaneous Findings and Endocrinopathies in Children with Turner Syndrome: A Cross-Sectional StudyJournal of clinical research in pediatric endocrinology · 2026Article
- Review
- Clinical and Genotypic Insights into Turner Syndrome: Emphasis on Cardiovascular Abnormalities.Journal of the ASEAN Federation of Endocrine Societies · 2025Article
- Analysis of influencing factors on Turner syndrome combined with autoimmune thyroid disease.Frontiers in endocrinology · 2025Article
- Associations of Karyotype and Age at Diagnosis with Physical Features and Comorbidities in Turner Syndrome: A Single-Site Experience.The application of clinical genetics · 2025Article
- Evaluating the relationship between the proportion of X-chromosome deletions and clinical manifestations in children with turner syndrome.Frontiers in endocrinology · 2024Article
- Components of the metabolic syndrome in girls with Turner syndrome treated with growth hormone in a long term prospective study.Frontiers in endocrinology · 2023Article
- Rash and cholestatic liver injury caused by methimazole in a woman with Turner syndrome and Graves's disease: a case report and literature review.BMC endocrine disorders · 2021Review
- Evaluation of Growth Hormone Results in Different Diagnosis and Trend Over 10 Year of Follow-up: A Single Center ExperienceJournal of clinical research in pediatric endocrinology · 2021Article
- The value of a simple method to decrease diagnostic errors in Turner syndrome: a case report.Journal of medical case reports · 2021Article
- Review
- Evaluation of Turner Syndrome Knowledge among Physicians and ParentsJournal of clinical research in pediatric endocrinology · 2020Article
- Turner syndrome in diverse populations.American journal of medical genetics. Part A · 2020Article
- Associated clinical abnormalities among patients with Turner syndrome.Northern clinics of Istanbul · 2020Article
- Liver Biochemical Abnormalities in Adolescent Patients with Turner SyndromeJournal of clinical research in pediatric endocrinology · 2019Article
- A Synopsis of Current Practice in the Diagnosis and Management of Patients with Turner Syndrome in Turkey: A Survey of 18 Pediatric Endocrinology CentersJournal of clinical research in pediatric endocrinology · 2018Article
Corrections and comments
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Authors and funding
74 authors at 20 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTurner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.
methodsOur retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.
resultsThe most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.
conclusionThis comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.