ReviewSchizophrenia bulletin2015
Magnetic resonance imaging and the prediction of outcome in first-episode schizophrenia: a review of current evidence and directions for future research.
Review in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cognitive change 5+ years since the onset of a psychotic disorder: A systematic review and meta-analysis.Psychological medicine · 2025Pooled it
- Prevalence of Neuroradiological Abnormalities in First-Episode Psychosis: A Systematic Review and Meta-analysis.JAMA psychiatry · 2023Pooled it
- Structural covariance networks in schizophrenia: A systematic review Part I.Schizophrenia research · 2022Pooled it
- Symptom Remission and Brain Cortical Networks at First Clinical Presentation of Psychosis: The OPTiMiSE Study.Schizophrenia bulletin · 2021Trial
- Frontal lobe functioning during a simple response conflict task in first-episode psychosis and its relationship to treatment response.Brain imaging and behavior · 2019Trial
- Structural alteration of neurons in schizophrenia and its relation with auditory hallucination.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- [Illness duration-related developmental trajectory of progressive cerebral gray matter changes in schizophrenia].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Elevated plasma matrix metalloproteinase 9 in schizophrenia patients associated with poor antipsychotic treatment response and white matter density deficits.Schizophrenia (Heidelberg, Germany) · 2024Article
- Identify Potential Causal Relationships Between Cortical Thickness, Mismatch Negativity, Neurocognition, and Psychosocial Functioning in Drug-Naïve First-Episode Psychosis Patients.Schizophrenia bulletin · 2024Article
- Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies.Translational psychiatry · 2023Article
- Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium.Molecular psychiatry · 2023Article
- Machine learning methods to predict outcomes of pharmacological treatment in psychosis.Translational psychiatry · 2023Review
- Advances in Using MRI to Estimate the Risk of Future Outcomes in Mental Health - Are We Getting There?Frontiers in psychiatry · 2022Article
- Reduced TMS-evoked fast oscillations in the motor cortex predict the severity of positive symptoms in first-episode psychosis.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis.NPJ schizophrenia · 2021Article
- Obesity as a Risk Factor for Accelerated Brain Ageing in First-Episode Psychosis-A Longitudinal Study.Schizophrenia bulletin · 2021Article
- Strategies to solve the reverse inference fallacy in future MRI studies of schizophrenia: a review.Brain imaging and behavior · 2021Review
- A multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Identification of Risk Factors to Predict the Occurrences of Relapses in Individuals with Schizophrenia Spectrum Disorder in Iran.International journal of environmental research and public health · 2021Article
- Emerging therapeutic targets for schizophrenia: a framework for novel treatment strategies for psychosis.Expert opinion on therapeutic targets · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
unlabelledMagnetic Resonance Imaging (MRI) measures are promising outcome markers for schizophrenia, since regional frontal and temporal grey matter volumes reductions, and enlargement of the ventricles, have been associated with outcome in this disorder. However, a number of methodological issues have limited the potential clinical utility of these findings. This article reviewed studies that examined brain structure at illness onset as a predictor of outcome, discusses the limitations of the findings, and highlights the challenges that would need to be addressed if structural data are to inform the management of an individual patient.
methodsUsing a set of a priori criteria, we systematically searched Medline and EMBASE databases for articles evaluating brain structure at the time of the first psychotic episode and assessed response to treatment, symptomatic outcome, or functional outcome at any point in the first 12 months of illness.
resultsThe 11 studies identified suggest that alterations in medial temporal and prefrontal cortical areas, and in the networks that connect them with subcortical structures, are promising neuroanatomical markers of poor symptomatic and functional outcomes.
conclusionNeuroimaging data, possibly in combination with other biomarkers of disease, could help stratifying patients with psychoses to generate patient clusters clinically meaningful, and useful to detect true therapeutic effects in clinical trials. Optimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE), a large multicenter study funded by the FP7 European Commission, could generate these much-needed findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.