Trial reportNeuroImage2017
Dopamine and memory dedifferentiation in aging.
Trial report in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 81 citations in OpenAlex.
- Trial
- Dopaminergic mechanisms supporting hippocampal postencoding dynamics in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effects of cortical thickness, volume, and memory performance on age differences in neural reinstatement of scene information.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Memory enhancing and neuroprotective effects of apomorphine in a rat model of dementia.Metabolic brain disease · 2024Article
- Mnemonic But Not Contextual Feedback Signals Defy Dedifferentiation in the Aging Early Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Age differences in neural distinctiveness during memory encoding, retrieval, and reinstatement.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Age Differences of the Hierarchical Cognitive Control and the Frontal Rostro-Caudal Functional Brain Activation.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Age-related neural dedifferentiation for individual stimuli: an across-participant pattern similarity analysis.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Article
- Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations.Neurobiology of aging · 2021Article
- Greater Neural Differentiation in the Ventral Visual Cortex Is Associated with Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness.Neurobiology of aging · 2021Article
- Tracking Age Differences in Neural Distinctiveness across Representational Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Working Memory Training in Amnestic and Non-amnestic Patients With Mild Cognitive Impairment: Preliminary Findings From Genotype Variants on Training Effects.Frontiers in aging neuroscience · 2021Article
- Age Differences In Retrieval-Related Reinstatement Reflect Age-Related Dedifferentiation At Encoding.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Article
- Neural Pattern Similarity Differentially Relates to Memory Performance in Younger and Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- How Multiple Retrievals Affect Neural Reactivation in Young and Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019Article
- Effects of age on across-participant variability of cortical reinstatement effects.NeuroImage · 2019Article
- Increased Prefrontal Activity with Aging Reflects Nonspecific Neural Responses Rather than Compensation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The dedifferentiation theory of aging proposes that a reduction in the specificity of neural representations causes declines in complex cognition as people get older, and may reflect a reduction in dopaminergic signaling. The present pharmacological fMRI study investigated episodic memory-related dedifferentiation in young and older adults, and its relation to dopaminergic function, using a randomized placebo-controlled double-blind crossover design with the agonist Bromocriptine (1.25mg) and the antagonist Sulpiride (400mg). We used multi-voxel pattern analysis to measure memory specificity: the degree to which distributed patterns of activity distinguishing two different task contexts during an encoding phase are reinstated during memory retrieval. As predicted, memory specificity was reduced in older adults in prefrontal cortex and in hippocampus, consistent with an impact of neural dedifferentiation on episodic memory representations. There was also a linear age-dependent dopaminergic modulation of memory specificity in hippocampus reflecting a relative boost to memory specificity on Bromocriptine in older adults whose memory was poorer at baseline, and a relative boost on Sulpiride in older better performers, compared to the young. This differed from generalized effects of both agents on task specificity in the encoding phase. The results demonstrate a link between aging, dopaminergic function and dedifferentiation in the hippocampus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.