Evidence map›Paper›PMID 25800038›Full record

ArticleEndocrine-related cancer2015

Development and characterization of a novel rat model of estrogen-induced mammary cancer.

Kirsten L Dennison, Nyssa Becker Samanas, Quincy Eckert Harenda, Maureen Peters Hickman, Nicole L Seiler, Lina Ding, James D Shull

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine-related cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Rat Models of Hormone Receptor-Positive Breast Cancer.Journal of mammary gland biology and neoplasia · 2024
    Review
  2. Large Animal Models of Breast Cancer.Frontiers in oncology · 2022
    Review
  3. Review
  4. Review
  5. Mapping Mammary Tumor Traits in the Rat.Methods in molecular biology (Clifton, N.J.) · 2019
    Review
  6. Review
  7. Genetic variation in sensitivity to estrogens and breast cancer risk.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Review
  8. Article
  9. Article
  10. Chemoprevention of Rat Mammary Carcinogenesis by Apiaceae Spices.International journal of molecular sciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kirsten L DennisonMcArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA.
Nyssa Becker SamanasMcArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA.
Quincy Eckert HarendaMcArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA.
Maureen Peters HickmanMcArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA.
Nicole L SeilerMcArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA.
Lina DingMcArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA McArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA.
James D ShullMcArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA McArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA McArdle Laboratory for Cancer ResearchDepartment of Oncology, School of Medicine and Public HealthSchool of Medicine and Public HealthMolecular and Environmental Toxicology CenterSchool of Medicine and Public HealthUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA shull@oncology.wisc.edu.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
GENETIC SUSCEPTIBILITY TO ESTROGEN INDUCED MAMMARY CAR01CA077876 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SHULL, JAMES D · 1998 to 2012
$4.4M
NCI NIH HHS P30 CA014520NCI NIH HHS P30-CA014520NCI NIH HHS R01 CA077876NCI NIH HHS R01-CA77876
6 · The paper itself

Abstract

The ACI rat model of 17β-estradiol (E2)-induced mammary cancer is highly relevant for use in establishing the endocrine, genetic, and environmental bases of breast cancer etiology and identifying novel agents and strategies for preventing breast cancer. E2 treatment rapidly induces mammary cancer in female ACI rats and simultaneously induces pituitary lactotroph hyperplasia and adenoma. The pituitary tumors can result in undesired morbidity, which compromises long-term studies focused on mammary cancer etiology and prevention. We have defined the genetic bases of susceptibility to E2-induced mammary cancers and pituitary tumors and have utilized the knowledge gained in these studies to develop a novel inbred rat strain, designated ACWi, that retains the high degree of susceptibility to E2-induced mammary cancer exhibited by ACI rats, but lacks the treatment-related morbidity associated with pituitary lactotroph hyperplasia/adenoma. When treated with E2, female ACWi rats developed palpable mammary cancer at a median latency of 116 days, an incidence of 100% by 161 days and exhibited an average of 15.6 mammary tumors per rat following 196 days of treatment. These parameters did not differ from those observed for contemporaneously treated ACI rats. None of the E2-treated ACWi rats were killed before the intended experimental end point due to any treatment-related morbidity other than mammary cancer burden, whereas 20% of contemporaneously treated ACI rats exhibited treatment-related morbidity that necessitated premature killing. The ACWi rat strain is well suited for use by those in the research community, focusing on breast cancer etiology and prevention.

Indexed as

Mammary Neoplasms, ExperimentalRats, Inbred StrainsAnimalsEstradiolFemalePhenotypePituitary GlandEstradiolACI ratACWi ratbreast cancerCopenhagen ratestradiol

Identifiers

PMID25800038
PMCPMC4372900
OpenAlexW1965875743

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.