ArticlePloS one2015
Epidemic 2014 enterovirus D68 cross-reacts with human rhinovirus on a respiratory molecular diagnostic platform.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis.PLoS neglected tropical diseases · 2022Pooled it
- Molecular epidemiology of human rhinovirus in coastal China: genotyping and epidemic trends in Daishan (2022-2023).Virus genes · 2026Article
- Sensitive detection and differentiation of rhinoviruses and enteroviruses by a nested real-time RT-PCR assay.Microbiology spectrum · 2026Article
- Enterovirus respiratory infection in adults: an overlooked clinical burden emerging in the post-pandemic era.Le infezioni in medicina · 2026Article
- Enterovirus A71 and coxsackievirus A6 circulation in England, UK, 2006-2017: A mathematical modelling study using cross-sectional seroprevalence data.PLoS pathogens · 2024Article
- First Detection of Enterovirus D68 in Korean Children, September 2022.Infection & chemotherapy · 2023Article
- Hunting for mpox (monkeypox) mimickers: Use of the Biofire meningitis/encephalitis panel on lesion swabs to support alternative viral diagnoses.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2023Article
- Comparative Evaluation of Allplex Respiratory Panels 1, 2, 3, and BioFire FilmArray Respiratory Panel for the Detection of Respiratory Infections.Diagnostics (Basel, Switzerland) · 2021Article
- Comparison of the AdvanSure RV Plus Real-Time RT-PCR and Real-Q RV II Detection Assays for Respiratory Viruses.Annals of laboratory medicine · 2021Article
- Comparison of children with acute flaccid myeltis before and after 2014.Neurology. Clinical practice · 2020Article
- Enterovirus D68-associated respiratory infection in southern Brazil, 2018 - A population-based laboratory surveillance.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
- Improved diagnostic policy for respiratory tract infections essential for patient management in the emergency department.Future microbiology · 2020Article
- Virus detections among patients with severe acute respiratory illness, Northern Vietnam.PloS one · 2020Article
- Enterovirus D68 serosurvey: evidence for endemic circulation in the Netherlands, 2006 to 2016.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Genomic analysis of serologically untypable human enteroviruses in Taiwan.Journal of biomedical science · 2019Article
- Evaluation of Performance Characteristics of Panther Fusion Assays for Detection of Respiratory Viruses from Nasopharyngeal and Lower Respiratory Tract Specimens.Journal of clinical microbiology · 2018Article
- Critical evaluation of FDA-approved respiratory multiplex assays for public health surveillance.Expert review of molecular diagnostics · 2018Review
- An array-based melt curve analysis method for the identification and classification of closely related pathogen strains.Biology methods & protocols · 2018Article
- Enterovirus D68 - The New Polio?Frontiers in microbiology · 2018Review
- A comparison of hospitalized children with enterovirus D68 to those with rhinovirus.Pediatric pulmonology · 2017Article
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Authors and funding
7 authors.
Funding
Abstract
Enterovirus D68 (EV-D68) is an emerging virus known to cause sporadic disease and occasional epidemics of severe lower respiratory tract infection. However, the true prevalence of infection with EV-D68 is unknown, due in part to the lack of a rapid and specific nucleic acid amplification test as well as the infrequency with which respiratory samples are analyzed by enterovirus surveillance programs. During the 2014 EV-D68 epidemic in the United States, we noted an increased frequency of "low-positive" results for human rhinovirus (HRV) detected in respiratory tract samples using the GenMark Diagnostics eSensor respiratory viral panel, a multiplex PCR assay able to detect 14 known respiratory viruses but not enteroviruses. We simultaneously noted markedly increased admissions to our Pediatric Intensive Care Unit for severe lower respiratory tract infections in patients both with and without a history of reactive airway disease. Accordingly, we hypothesized that these "low-positive" RVP results were due to EV-D68 rather than rhinovirus infection. Sequencing of the picornavirus 5' untranslated region (5'-UTR) of 49 samples positive for HRV by the GenMark RVP revealed that 33 (67.3%) were in fact EV-D68. Notably, the mean intensity of the HRV RVP result was significantly lower in the sequence-identified EV-D68 samples (20.3 nA) compared to HRV (129.7 nA). Using a cut-off of 40 nA for the differentiation of EV-D68 from HRV resulted in 94% sensitivity and 88% specificity. The robust diagnostic characteristics of our data suggest that the cross-reactivity of EV-D68 and HRV on the GenMark Diagnostics eSensor RVP platform may be an important factor to consider in making accurate molecular diagnosis of EV-D68 at institutions utilizing this system or other molecular respiratory platforms that may also cross-react.
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