ArticleNature communications2015
Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- HOPX regulates the development and lineage progression of human stem cell-derived outer radial glia-like cells.Stem cell reports · 2026Article
- Sodium Butyrate-Assisted Induction of Posterior Pre-Neural Progenitors from Pluripotent Stem Cells.International journal of molecular sciences · 2026Article
- Composition and activity of the proteasome in human iPSC-derived neuronal model of early-stage sporadic Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- The hippocampal subgranular zone neurogenic niche: a modular perspective on neural stem cell regulation.Frontiers in cellular neuroscience · 2026Review
- Article
- Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components.Scientific reports · 2025Article
- Molecular Characterization of Subdomain Specification of Cochlear Duct Based on Foxg1 and Gata3.International journal of molecular sciences · 2024Article
- Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids.Scientific reports · 2024Article
- Brain organoids: A revolutionary tool for modeling neurological disorders and development of therapeutics.Biotechnology and bioengineering · 2024Review
- Human cortical spheroids with a high diversity of innately developing brain cell types.Stem cell research & therapy · 2023Article
- The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties.EMBO reports · 2023Article
- Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain.Epigenetics & chromatin · 2022Review
- Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells.Nature cell biology · 2022Article
- Signal requirement for cortical potential of transplantable human neuroepithelial stem cells.Nature communications · 2022Article
- Advancing models of neural development with biomaterials.Nature reviews. Neuroscience · 2021Review
- Soft surfaces promote astrocytic differentiation of mouse embryonic neural stem cells via dephosphorylation of MRLC in the absence of serum.Scientific reports · 2021Article
- Atypical Neurogenesis in Induced Pluripotent Stem Cells From Autistic Individuals.Biological psychiatry · 2021Article
- Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis.Cell reports · 2021Article
- Organoids: a novel modality in disease modeling.Bio-design and manufacturing · 2021Review
- The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects.Frontiers in cellular neuroscience · 2021Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decoding heterogeneity of pluripotent stem cell (PSC)-derived neural progeny is fundamental for revealing the origin of diverse progenitors, for defining their lineages, and for identifying fate determinants driving transition through distinct potencies. Here we have prospectively isolated consecutively appearing PSC-derived primary progenitors based on their Notch activation state. We first isolate early neuroepithelial cells and show their broad Notch-dependent developmental and proliferative potential. Neuroepithelial cells further yield successive Notch-dependent functional primary progenitors, from early and midneurogenic radial glia and their derived basal progenitors, to gliogenic radial glia and adult-like neural progenitors, together recapitulating hallmarks of neural stem cell (NSC) ontogeny. Gene expression profiling reveals dynamic stage-specific transcriptional patterns that may link development of distinct progenitor identities through Notch activation. Our observations provide a platform for characterization and manipulation of distinct progenitor cell types amenable for developing streamlined neural lineage specification paradigms for modelling development in health and disease.
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