ArticlePloS one2015
Pathological features of localized prostate cancer in China: a contemporary analysis of radical prostatectomy specimens.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Body mass weighted prostate-specific antigen levels, new markers to predict locally advanced prostate cancer after prostatectomy.Journal of the Chinese Medical Association : JCMA · 2024Article
- RP1-59D14.5 triggers autophagy and represses tumorigenesis and progression of prostate cancer via activation of the Hippo signaling pathway.Cell death & disease · 2022Article
- Tumor Biological Feature and Its Association with Positive Surgical Margins and Apical Margins after Radical Prostatectomy in Non-Metastasis Prostate Cancer.Current oncology (Toronto, Ont.) · 2021Article
- Morbidity and All-Cause Mortality Following Radical Prostatectomy Compared with Observation for Localized Prostate Cancer in Chinese Men: A Non-Randomized Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- lncRNA HAND2-AS1 Regulates Prostate Cancer Cell Growth Through Targeting the miR-106a-5p/RBM24 Axis.OncoTargets and therapy · 2020Article
- Knockdown of lncRNA PVT1 inhibits prostate cancer progression in vitro and in vivo by the suppression of KIF23 through stimulating miR-15a-5p.Cancer cell international · 2020Article
- Clinical significance of bromodomain-containing protein 7 and its association with tumor progression in prostate cancer.Oncology letters · 2019Article
- Current Treatment for Low-Risk Prostate Cancer in China: A National Network Survey.Journal of Cancer · 2019Article
- Zeylenone represses the progress of human prostate cancer by downregulating the Wnt/β‑catenin pathway.Molecular medicine reports · 2018Article
- Downregulation of lncRNA PVT1 expression inhibits proliferation and migration by regulating p38 expression in prostate cancer.Oncology letters · 2018Article
- Effect of body mass index on the performance characteristics of PSA-related markers to detect prostate cancer.Scientific reports · 2016Article
- Survivin mRNA-circulating tumor cells are associated with prostate cancer metastasis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Sodium phenylbutyrate antagonizes prostate cancer through the induction of apoptosis and attenuation of cell viability and migration.OncoTargets and therapy · 2016Article
- Development and external validation of a prostate health index-based nomogram for predicting prostate cancer.Scientific reports · 2015Article
- [Effect of sodium phenylbutyrate on the sensitivity of PC3/DTX-resistant prostate cancer cells to docetaxel].Nan fang yi ke da xue xue bao = Journal of Southern Medical UniversityArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been a rapid increase in the incidence of prostate cancer in China, especially in areas with boosted economic development. In this study, we analyzed the pathological features of a contemporary series of radical prostatectomy cases. A total of 230 consecutive, whole-mounted radical prostatectomy specimens collected from 2012 to 2014 were reviewed. The median age of the patients was 68 years, and 64.3% of patients presented with prostate specific antigen alone. Pathological examination indicated that a high proportion (77.4%) of patients had intermediate- or high-risk disease according to the Cancer of the Prostate Risk Assessment Post-Surgical score. After surgery, only 28 patients met the criteria for active surveillance (organ-confined Gleason ≥6 disease). The Prostate Cancer Research International Active Surveillance criteria achieved a sensitivity of 57.1% and a specificity of 98.0% for identifying candidates. The probability of Gleason score upgrading was 24.8% in the entire group and 59.0% in biopsy-confirmed Gleason ≥6 disease. The predominant tumor was located in the transition zone in 14.8% of cases, while only three patients (1.3%) had a predominant tumor located in the anterior region. Patients with transition zone-predominant tumor were likely to have been referred with urinary symptoms and high prostate specific antigen levels. The results of this study highlight the contemporary pathological features of localized prostate cancer in urban China. There was an increased trend towards asymptomatic cases, though most patients had intermediate- or high-risk disease and were suitable for definitive treatment. The low prevalence of dominant cancer in the anterior region may reflect race-based pathological differences.
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