Evidence map›Paper›PMID 25798682›Full record

ReviewBone marrow transplantation2015

Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT).

M Mohty, F Malard, M Abecassis, E Aerts, A S Alaskar, M Aljurf, M Arat, P Bader, F Baron, A Bazarbachi and 20 more

2 registry-linked trialsAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone marrow transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 174 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03426358 nacompletednot on this map

Usefulness of Liver Stiffness Measurement in Predicting Hepatic Veno-Occlusive Disease Development in Patients Who Undergo HSCT: a Multicentric Prospective Study

TypeinterventionalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2015 to 2021Enrolled1,101ConditionsVeno Occlusive Disease, Hepatic, Sinusoidal Obstruction Syndrome, Stem Cell Transplant ComplicationsArmsLSM assessed by Elastographic Techniques
NCT04712435 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Prospective, Randomized Study Using N-Acetylcysteine as Prophylaxis of Sinusoidal Obstruction Syndrome in Patients Undergoing Hematopoietic Stem Cell Transplantation

TypeinterventionalSponsorInstituto Brasileiro de Controle do CancerRan2021 to 2023Enrolled80ConditionsSinusoidal Obstruction Syndrome (SOS), Hematopoietic Stem Cell Transplant (HSCT)ArmsN-acetylcysteine, Placebo
3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  3. [Chinese guideline for diagnosis and management of drug-induced liver injury (2023 version)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

M MohtyHematology department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France.
F MalardHematology department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France.
M AbecassisInst Portugues Oncologia, Lisboa, Portugal.
E AertsDepartment of Haematology, University Hospital Zurich, Zurich, Switzerland.
A S AlaskarKing Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Department of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
M AljurfKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
M AratSisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
P BaderDivision for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
F BaronDepartment of Hematology, University of Liege, Liege, Belgium.
A BazarbachiDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.
D BlaiseBlood and Marrow Transplantation Program, Hematology Department, Institut Paoli-Calmettes, Marseille, France.
F CiceriHematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
S CorbaciogluDepartment of Hematology, Oncology, and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
J-H DalleDepartment of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
R F DuarteDepartment of Haematology, Institut Català d'Oncología (ICO) - Hospital Duran i Reynals, Hospitalet de Llobregat, Barcelona, Spain.
T FukudaHSCT division, National Cancer Center Hospital, Tokyo, Japan.
A HuynhHematology department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
T MassziDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest 3 Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
M MichalletHematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon EST, Pierre Bénite, France.
A NaglerHematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
M NiChonghaileNational Stem Cell Transplant Unit (Adults), Department of Haematology, St James's Hospital and Academic Department of Haematology, Trinity College Dublin, Dublin, Ireland.
T PagluicaDepartment of Haematology, King's College Hospital, London, UK.
C PetersDepartment of Pediatrics, St. Anna Kinderspital, Vienna, Austria.ORCID 0000000303698515
F B PetersenLDS Hospital, Salt Lake City, UT, USA.
P G RichardsonDivision of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
T RuutuComprehensive Cancer Center, Helsinki University Central Hospital, Helsinki, Finland.
B N SavaniHematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, TN, USA.
E WallhultSection of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
I Yakoub-AghaBone Marrow Transplantation Unit, CHU de Lille, Lille, France.
E Carreras1] Josep Carreras Leukaemia Research Institute, Barcelona, Spain [2] Haematology Department, Hospital Clinic, Barcelona, Spain [3] Spanish Bone Marrow Donor Program, Josep Carreras Foundation, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children.

Indexed as

Postoperative ComplicationsVascular DiseasesAdultBiomarkersHematopoietic Stem Cell TransplantationHumansRisk FactorsBiomarkers

Identifiers

PMID25798682
PMCPMC4456788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.