ArticleBehavioral neuroscience2015
Modeling Parkinson's disease falls associated with brainstem cholinergic systems decline.
Article in Behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The brain map of gait variability in aging, cognitive impairment and dementia-A systematic review.Neuroscience and biobehavioral reviews · 2017Pooled it
- Deltex 2 Mediates Oxidative Stress and Neurotoxicity in Freezing of Gait of Parkinson's Disease via the Notch2-Nrf2 Axis.CNS neuroscience & therapeutics · 2026Article
- The central cholinergic system as a therapeutic target in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- A multicenter longitudinal study of cholinergic subgroups in Parkinson disease.Nature communications · 2025Article
- The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson's disease.Frontiers in neural circuits · 2023Review
- Reduction of falls in a rat model of PD falls by the M1 PAM TAK-071.Psychopharmacology · 2021Article
- Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson's Disease.Frontiers in neuroscience · 2021Review
- Association of Postural Instability with Autonomic Dysfunction in Early Parkinson's Disease.Journal of clinical medicine · 2020Article
- Complex Movement Control in a Rat Model of Parkinsonian Falls: Bidirectional Control by Striatal Cholinergic Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The pedunclopontine nucleus and Parkinson's disease.Neurobiology of disease · 2019Review
- Bottom-up gamma maintenance in various disorders.Neurobiology of disease · 2019Review
- Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson's disease.Psychopharmacology · 2019Article
- Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson's disease.NeuroImage · 2019Article
- Basal forebrain chemogenetic inhibition disrupts the superior complex movement control of goal-tracking rats.Behavioral neuroscience · 2019Article
- Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board.Movement disorders : official journal of the Movement Disorder Society · 2018Review
- Addiction vulnerability trait impacts complex movement control: Evidence from sign-trackers.Behavioural brain research · 2018Article
- Gait Patterns in Parkinson's Disease with or without Cognitive Impairment.Dementia and neurocognitive disorders · 2018Article
- Cholinergic Pathway SNPs and Postural Control in 477 Older Adults.Frontiers in aging neuroscience · 2018Article
- Review
- Brainstem control of locomotion and muscle tone with special reference to the role of the mesopontine tegmentum and medullary reticulospinal systems.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In addition to the primary disease-defining symptoms, approximately half of patients with Parkinson's disease (PD) suffer from postural instability, impairments in gait control and a propensity for falls. Consistent with evidence from patients, we previously demonstrated that combined striatal dopamine (DA) and basal forebrain (BF) cholinergic cell loss causes falls in rats traversing dynamic surfaces. Because evidence suggests that degeneration of brainstem cholinergic neurons arising from the pedunculopontine nucleus (PPN) also contributes to impaired gait and falls, here we assessed the effects of selective cholinergic PPN lesions in combination with striatal DA loss or BF cholinergic cells loss as well as losses in all 3 regions. Results indicate that all combination losses that included the BF cholinergic system slowed traversal and increased slips and falls. However, the performance of rats with losses in all 3 regions (PPN, BF, and DA) was not more severely impaired than following combined BF cholinergic and striatal DA lesions. These results confirm the hypothesis that BF cholinergic-striatal disruption of attentional-motor interactions is a primary source of falls. Additional losses of PPN cholinergic neurons may worsen posture and gait control in situations not captured by the current testing conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.