ArticlePloS one2015
Comparative experimental study of wound healing in mice: Pelnac versus Integra.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
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- Development of gelatin hydrogel nonwoven fabrics (Genocel®) as a novel skin substitute in murine skin defects.Regenerative therapy · 2022Article
- Comparison of Wound Healing Effect of Skin Micrograft Impregnated into Two Kinds of Artificial Dermis in a Murine Wound Model.Plastic and reconstructive surgery. Global open · 2022Article
- Tie-Over Bolster Pressure Dressing Improves Outcomes of Skin Substitutes Xenografts on Athymic Mice.International journal of molecular sciences · 2022Article
- Skin substitutes with noncultured autologous skin cell suspension heal porcine full-thickness wounds in a one-stage procedure.International wound journal · 2022Article
- Selection of Artificial Dermis for Shortening Treatment Period: Integra versus Pelnac.Plastic and reconstructive surgery. Global open · 2021Article
- Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves ofJournal of experimental pharmacology · 2021Article
- Artificial dermal substitutes for tissue regeneration: comparison of the clinical outcomes and histological findings of two templates.The Journal of international medical research · 2020Observational
- Microwave assisted synthesis of polyacrylamide grafted polymeric blend of fenugreek seed mucilage-Polyvinyl alcohol (FSM-PVA-g-PAM) and its characterizations as tissue engineered scaffold and as a drug delivery device.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Article
- Integrated sensing and delivery of oxygen for next-generation smart wound dressings.Microsystems & nanoengineering · 2020Article
- Utility of a New Artificial Dermis as a Successful Tool in Face and Scalp Reconstruction for Skin Cancer: Analysis of the Efficacy, Safety, and Aesthetic Outcomes.Dermatology research and practice · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strategies for skin regeneration have been developed to provide effective treatment for cutaneous wounds and disease. Dermal substitutes have been used to cover the lesion to facilitate cell colonization, thereby promoting dermal regeneration. However, very little is known about Pelnac matrix especially at histological level. Therefore, the present work carried out an experimental in vivo comparative analysis between Pelnac and Integra, the most used dermal templates, in a mouse model of full-thickness skin wounds. Histological sections performed at the 3rd, 6th and 9th days after surgery were analyzed with regard to inflammatory response and vascularization. Both templates were completely incorporated in all animals at the end of the analyzed period. Pelnac-treated animals displayed reduced granulation tissue during the first 6 days of treatment compared to the animals treated with Integra at the same time period. The number of inflammatory cells (neutrophils) was similar in both groups during the period, significantly reducing at the end of inflammatory phase (9th day of treatment) consistent with the progression of healing process. In addition, the density of blood vessels was also statistically similar in both matrices. Therefore, the two dermal templates displayed comparable biological behavior in tissue repair. It is noteworthy that this is the first experimental study comparing Pelnac and Integra dermal templates with focus on full-thickness skin wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.